Evidence map›Paper›PMID 29462012›Full record

ReviewAnesthesiology2018

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.

Ru-Rong Ji, Andrea Nackley, Yul Huh, Niccolò Terrando, William Maixner

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 936 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
936citing papers in PubMed, 10 pooled it
47.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04271072 completednot on this mapstarted 2020, after this paper: background citation

The Role of Cerebrospinal Fluid and Serum Inflammatory Biomarkers in Predicting Perinatal Depression and Persistent Pain After Cesarean Delivery

TypeobservationalSponsorDuke UniversityRan2020 to 2022Enrolled81ConditionsPerinatal Depression, Chronic PainArmsNo intervention
NCT06957873 recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Relationship Between Craniovertebral Angle and Fibromyalgia Symptom Severity

TypeobservationalSponsorAnkara Training and Research HospitalRan2025 to 2026Enrolled134ConditionsCraniovertebral Angle, Fibromyalgia Syndrome
NCT07567300 recruitingnot on this mapstarted 2026, after this paper: background citation

From Mechanisms to Clinical Evidence: A Cross-Sectional Study of Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain

Typeobservational_patient_registrySponsorBozok UniversityRan2026 to 2026Enrolled179ConditionsNeck Pain, Migraine, Low Back Pain
3 · Its place in the literature

Who cites it

936 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,454 citations in OpenAlex.

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876 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Ru-Rong JiFrom the Center for Translational Pain Medicine, Departments of Anesthesiology (R.-R.J., A.N., Y.H., N.T., W.M.) Neurobiology (R.-R.J.) Pharmacology (A.N.), Duke University Medical Center, Durham, North Carolina.
Andrea Nackley
Yul Huh
Niccolò Terrando
William Maixner
Duke University · US

Funding

Neuronal and glial interactions of neuropathic painR01DE017794 · NIDCR · DUKE UNIVERSITY · PI BUCHHEIT, THOMAS · 2006 to 2021
$6.6M
Hemichannels, Astrocytic Release, and Neuropathic PainR01DE022743 · NIDCR · DUKE UNIVERSITY · PI JI, RU-RONG, NEDERGAARD, MAIKEN · 2012 to 2016
$2.0M
Resolution pathway of painR01NS087988 · NINDS · DUKE UNIVERSITY · PI JI, RU-RONG · 2014 to 2018
$1.7M
Treating chemotherapy-induced neuropathic pain by targeted silencing of A-fibersR21NS091779 · NINDS · DUKE UNIVERSITY · PI JI, RU-RONG · 2015 to 2016
$437k
NIDCR NIH HHS R01 DE017794NIDCR NIH HHS R01 DE022743NINDS NIH HHS R01 NS087988NINDS NIH HHS R21 NS091779
6 · The paper itself

Abstract

Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness in central pain pathways after painful insults. Accumulating evidence suggests that central sensitization is also driven by neuroinflammation in the peripheral and central nervous system. A characteristic feature of neuroinflammation is the activation of glial cells, such as microglia and astrocytes, in the spinal cord and brain, leading to the release of proinflammatory cytokines and chemokines. Recent studies suggest that central cytokines and chemokines are powerful neuromodulators and play a sufficient role in inducing hyperalgesia and allodynia after central nervous system administration. Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affects multiple body sites. Thus, neuroinflammation drives widespread chronic pain via central sensitization. We also discuss sex-dependent glial/immune signaling in chronic pain and new therapeutic approaches that control neuroinflammation for the resolution of chronic pain.

Indexed as

AnalgesicsAnimalsCentral Nervous System SensitizationChronic PainClinical Trials as TopicGliosisHumansInflammationInflammation MediatorsPain ManagementAnalgesicsInflammation Mediators

Identifiers

PMID29462012
PMCPMC6051899
OpenAlexW2786697307

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.