Evidence map›Paper›PMID 29463568›Full record

ArticleJournal of lipid research2018

An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort.

Xin Geng, Marguerite R Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis C Frazier-Wood, Hemant K Tiwari, Tushar Dave, Kathleen Ryan and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Testing SIPA1L2 as a modifier of CMT1A using mouse models.Journal of neuropathology and experimental neurology · 2024
    Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Xin GengSchool of Biomedical Informatics The University of Texas Health Science Center at Houston, Houston, TX 77030.
Marguerite R IrvinDepartments of Epidemiology University of Alabama at Birmingham, Birmingham, AL 35233.
Bertha HidalgoDepartments of Epidemiology University of Alabama at Birmingham, Birmingham, AL 35233.
Stella AslibekyanDepartments of Epidemiology University of Alabama at Birmingham, Birmingham, AL 35233.
Vinodh SrinivasasainagendraBiostatistics, University of Alabama at Birmingham, Birmingham, AL 35233.
Ping AnDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Alexis C Frazier-WoodUS Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030.
Hemant K TiwariBiostatistics, University of Alabama at Birmingham, Birmingham, AL 35233.
Tushar DaveDepartment of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.
Kathleen RyanDepartment of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.
Jose M OrdovasNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111; Instituto Madrileño de Estudios Avanzados en Alimentación, Madrid 28049, Spain; Centro Nacional Investigaciones Cardiovasculares, Madrid 28029, Spain.
Robert J StrakaDepartment of Experimental and Clinical Pharmacology Minneapolis, University of Minnesota, MN 55455.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Paul N HopkinsDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, UT 84112.
Ingrid BoreckiGenetic Analysis Center, Department of Biostatistics, University of Washington, Seattle, WA 98105.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Braxton D MitchellDepartment of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY 40506. Electronic address: donna.arnett@uky.edu.
Degui ZhiSchool of Biomedical Informatics The University of Texas Health Science Center at Houston, Houston, TX 77030; School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030. Electronic address: Degui.Zhi@uth.tmc.edu.
University of Alabama at Birmingham · USUniversity of Maryland, Baltimore · USThe University of Texas Health Science Center at Houston · USAgricultural Research Service · USMadrid Institute for Advanced Studies · ESUniversity of Kentucky · USUniversity of Minnesota · USUniversity of Utah · USUniversity of Washington · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Genetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9M
Genome-wide Search for CVD Gene-Environment InteractionsU01HL072515 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2002 to 2008
$11.2M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genomewide Association Study of Lipid Response to Fenofibrate and Dietary FatR01HL091357 · NHLBI · UNIVERSITY OF KENTUCKY · PI ARNETT, DONNA K · 2008 to 2018
$5.8M
Identification and Functional characterization of a gene influencing LDL-C on 5qR01HL121007 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2014 to 2017
$3.1M
NHLBI NIH HHS R01 HL091357NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL121007NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL072524NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therapy in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort using an exome-wide sequencing-based association study. Our results showed that the rare coding variants in

Indexed as

Cohort StudiesDietary FatsDNA MethylationExomeFenofibrateHumansLipidsSequence Analysis, RNAWhite PeopleDietary FatsFenofibrateLipidscholesterolepidemiologygeneticshigh-density lipoproteinlow-density lipoproteinpostprandial lipemiarare varianttriglyceridewhole-exome sequencing

Identifiers

PMID29463568
PMCPMC5880495
OpenAlexW2788155523

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.