Evidence map›Paper›PMID 29464887›Full record

ReviewPediatric diabetes2018

Factitious hypoglycemia in children and adolescents with diabetes.

Viviana Bauman, Adaya C Sturkey, Rosa Sherafat-Kazemzadeh, Jennifer McEwan, Paul M Jones, Ashley Keating, Elvira Isganaitis, Alyne Ricker, Kristina I Rother

Abstract readCase ReportsReview
In one paragraph

Review in Pediatric diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Insulin-Related Disordered Eating Behavior: Clarifying Terminology.The International journal of eating disorders · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Viviana BaumanSection of Pediatric Diabetes and Metabolism, DEOB, NIDDK, NIH, Bethesda, Maryland.
Adaya C SturkeySection of Pediatric Diabetes and Metabolism, DEOB, NIDDK, NIH, Bethesda, Maryland.
Rosa Sherafat-KazemzadehDepartment of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia.
Jennifer McEwanDepartment of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia.
Paul M JonesDepartment of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia.
Ashley KeatingPediatric, Adolescent and Young Adult Unit, Joslin Diabetes Center, Boston, Massachusetts.
Elvira IsganaitisPediatric, Adolescent and Young Adult Unit, Joslin Diabetes Center, Boston, Massachusetts.
Alyne RickerPediatric, Adolescent and Young Adult Unit, Joslin Diabetes Center, Boston, Massachusetts.
Kristina I RotherSection of Pediatric Diabetes and Metabolism, DEOB, NIDDK, NIH, Bethesda, Maryland.ORCID 0000-0002-8421-131X
Georgetown University · USJoslin Diabetes Center · USNational Institutes of Health · US

Funding

Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115, 10-DK-0163)ZIADK047049 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2009 to 2019
$4.4M
Beta-Cell Rest in Adolescents and Young Adults with Type 2 Diabetes (07-DK-0115)Z01DK047049 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BALOW, JAMES · 2008 to 2008
$445k
Intramural NIH HHS Z01 DK047049Intramural NIH HHS ZIA DK047049
6 · The paper itself

Abstract

backgroundFactitious hypoglycemia is a condition of self-induced hypoglycemia due to surreptitious administration of insulin or oral hypoglycemic agents. In adults, it is an uncommon, but well known clinical entity observed in individuals with and without diabetes.

objectivesTo report a case of factitious hypoglycemia highlighting diagnostic pitfalls, to identify common characteristics of children and adolescents with factitious hypoglycemia, and to examine whether the information on long-term outcome exists.

methodsWe present a case of an adolescent with type 1 diabetes who had self-induced hypoglycemia of several years' duration; and we conducted a systematic literature review on factitious hypoglycemia in pediatric patients with diabetes.

resultsWe identified a total of 83 articles of which 14 met the inclusion criteria (describing 39 cases). All but 1 individual had type 1 diabetes and the majority was female (63%). Average age was 13.5 ± 2.0 years with the youngest patient presenting at the age 9.5 years. Blood glucose control was poor (hemoglobin A1c: 12.1 ± 4.0%). In 35%, psychiatric disorders were mentioned as contributing factors. Only 3 reports provided follow-up beyond 6 months.

conclusionsFactitious hypoglycemia typically occurs in adolescents with type 1 diabetes who use insulin to induce hypoglycemia. Awareness of this differential diagnosis and knowledge of potentially misleading laboratory results may facilitate earlier recognition and intervention. Little information exists on effective treatments and long-term outcome.

Indexed as

AdolescentBlood GlucoseDiabetes Mellitus, Type 1Diagnosis, DifferentialFactitious DisordersFemaleHumansHypoglycemiaInsulinBlood GlucoseInsulinfactitioushypoglycemiaMünchausenpediatric diabetessurreptitious

Identifiers

PMID29464887
PMCPMC5938100
OpenAlexW2789314183

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.