Evidence map›Paper›PMID 29476979›Full record

ReviewBone2019

Bone and blood interactions in human health and disease.

Rodrigo J Valderrábano, Joy Y Wu

Open access · greenAbstract readReview
In one paragraph

Review in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Alendronate preserves bone mineral density in adults with sickle cell disease and osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022
    Review
  18. Review
  19. Associations of hemoglobin and change in hemoglobin with risk of incident hip fracture in older men and women: the cardiovascular health study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  20. High platelet count is associated with low bone mineral density: The MrOS Sweden cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rodrigo J ValderrábanoDivision of Endocrinology, University of Miami Miller School of Medicine, Miami, FL, United States. Electronic address: rvalderrabano@med.miami.edu.
Joy Y WuDivision of Endocrinology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: jywu1@stanford.edu.
Stanford Medicine · USUniversity of Miami · US

Funding

"In vivo reconstitution of the hematopoietic niche"DP2OD008466 · OD · STANFORD UNIVERSITY · PI WU, JOY Y · 2011 to 2011
$2.4M
NIH HHS DP2 OD008466
6 · The paper itself

Abstract

Under physiologic conditions hematopoiesis takes place in the bone marrow, and the skeleton provides the structural and supportive network necessary for normal hematopoiesis. Chronic disorders affecting hematopoiesis such as sickle cell anemia and thalassemia demonstrate striking skeletal phenotypes including bone loss and increased fracture risk. There is mounting evidence that anemia in older populations may also be associated with bone fragility. Given the interconnectedness of bone and hematopoietic cells, it is important to review the potential clinical implications and opportunities for therapeutic intervention. There are recognized associations between blood-borne and solid tissue malignancy and skeletal health, but our review will focus on non-malignant disease.

Indexed as

DiseaseHealthBloodBone and BonesBone DensityHematopoiesisHumansAnemiaBone healthBone mineral densityFractureHematopoiesisOsteoporosis

Identifiers

PMID29476979
PMCPMC11370649
OpenAlexW2794056539

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.