Evidence map›Paper›PMID 29480331›Full record

ArticlePflugers Archiv : European journal of physiology2018

Relaxant effect of ghrelin on guinea pig isolated tracheal smooth muscle: role of epithelial NO and PGE

Mohammed Saeed Zayed Al-Ayed

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mohammed Saeed Zayed Al-AyedDepartment of Pediatrics, College of Medicine, Najran University, Najran, Saudi Arabia. drmzayed2000@yahoo.com.
Najran University · SA

Funding

King Abdulaziz City for Science and Technology A.T. 34/116
6 · The paper itself

Abstract

This study aimed at investigating the potential ghrelin relaxing effect on guinea pig isolated tracheal smooth muscle (TSM). Using an in vitro experimental approach, the physiological role of the airway epithelium on smooth muscle relaxation has been investigated by analyzing the dose-response curves for carbachol- or histamine-induced contractions on epithelium intact versus denuded tracheal tissue. The relaxant effect of ghrelin (5-200 μmol/L) then investigated on carbachol-contracted, non-sensitized, and ovalbumin (OVA)-sensitized guinea pig TSM with an intact or denuded epithelium. The isolated TSMs from identical guinea pigs were incubated in Krebs solution aerated with 95% O

Indexed as

Muscle RelaxationAnimalsCarbacholDinoprostoneGhrelinGuinea PigsHistamineIndomethacinMaleMuscle, SmoothNG-Nitroarginine Methyl EsterNitric OxidePiperidinesQuinazolinonesRespiratory MucosaTracheaCarbacholDinoprostoneGhrelinHistamineIndomethacinNG-Nitroarginine Methyl EsterNitric OxidePiperidinesQuinazolinonesYIL 781Epithelial NOGhrelinGuinea pigPGE2Smooth muscles

Identifiers

PMID29480331
OpenAlexW2794330090

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.