Evidence map›Paper›PMID 29487137›Full record

ArticleGenetics2018

Seven-Up Is a Novel Regulator of Insulin Signaling.

Laura Palanker Musselman, Jill L Fink, Ezekiel J Maier, Jared A Gatto, Michael R Brent, Thomas J Baranski

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Developmental patterning of adipose tissue bybioRxiv : the preprint server for biology · 2026
    Article
  2. Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026
    Review
  3. Lipid Metabolism as a Target Site in Pest Control.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Disease models & mechanisms · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Laura Palanker MusselmanDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 lmusselm@binghamton.edu.ORCID 0000-0002-8478-2526
Jill L FinkDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Ezekiel J MaierDepartment of Computer Science, and Department of Genetics and.
Jared A GattoDepartment of Biological Sciences, Binghamton University, New York 13902.
Michael R BrentDepartment of Computer Science, Washington University in St. Louis, Missouri 63110.ORCID 0000-0002-8689-0299
Thomas J BaranskiDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.ORCID 0000-0002-4699-5192
Washington University in St. Louis · USBinghamton University · USPediatrics and Genetics · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTHK12HD001459 · NICHD · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2000 to 2014
$6.9M
NICHD NIH HHS K12 HD001459NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P60 DK020579
6 · The paper itself

Abstract

Insulin resistance is associated with obesity, cardiovascular disease, non-alcoholic fatty liver disease, and type 2 diabetes. These complications are exacerbated by a high-calorie diet, which we used to model type 2 diabetes in

Indexed as

Signal TransductionAdipose TissueAnimal FeedAnimalsDNA-Binding ProteinsDrosophila melanogasterDyslipidemiasEnergy MetabolismFemaleGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksGlucoseHomeostasisInsulinDNA-Binding ProteinsGlucoseInsulinReceptors, Steroidsvp protein, DrosophiladiabetesDrosophilaecdysone receptorobesitySeven-up

Identifiers

PMID29487137
PMCPMC5887154
OpenAlexW2788473066

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.