Evidence map›Paper›PMID 29487166›Full record

ArticleThe Biochemical journal2018

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through

Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, Choayang Wang, Leng Hiong Lim, Lili Sun, Ian Chambers, Thorsten Wohland, Paul Robson

Open access · hybridAbstract read
In one paragraph

Article in The Biochemical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
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  9. Journey of the mouse primitive endoderm: from specification to maturation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  10. Article
  11. Pluripotent Core in Bovine Embryos: A Review.Animals : an open access journal from MDPI · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Tapan Kumar MistriSchool of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Wibowo ArindrartoDevelopmental Cellomics Laboratory, Genome Institute of Singapore, Singapore.
Wei Ping NgDepartment of Chemistry, National University of Singapore, Singapore.
Choayang WangDevelopmental Cellomics Laboratory, Genome Institute of Singapore, Singapore.
Leng Hiong LimDevelopmental Cellomics Laboratory, Genome Institute of Singapore, Singapore.
Lili SunDevelopmental Cellomics Laboratory, Genome Institute of Singapore, Singapore.
Ian ChambersMRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, U.K. ichambers@ed.ac.uk twohland@nus.edu.sg paul.robson@jax.org.ORCID 0000-0003-2605-1597
Thorsten WohlandDepartment of Chemistry, National University of Singapore, Singapore ichambers@ed.ac.uk twohland@nus.edu.sg paul.robson@jax.org.
Paul RobsonDevelopmental Cellomics Laboratory, Genome Institute of Singapore, Singapore ichambers@ed.ac.uk twohland@nus.edu.sg paul.robson@jax.org.
Genome Institute of Singapore · SGNational University of Singapore · SGJackson Laboratory · USLovely Professional University · INMRC Centre for Regenerative Medicine · GB

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Medical Research Council MR/K017047/1Medical Research Council MR/L018497/1NCI NIH HHS P30 CA034196
6 · The paper itself

Abstract

Oct4 and Sox2 regulate the expression of target genes such as

Indexed as

AnimalsBlastocystCell DifferentiationCell LineageCells, CulturedCHO CellsCricetinaeCricetulusEmbryo, MammalianEndodermFemaleFibroblast Growth Factor 4Gene Expression Regulation, DevelopmentalMicePregnancyReceptor, Fibroblast Growth Factor, Type 2Fgf4 protein, mouseFgfr2 protein, mouseFibroblast Growth Factor 4Receptor, Fibroblast Growth Factor, Type 2Sox2 protein, mouseSOXB1 Transcription Factorscooperativityfluorescence correlation spectroscopy (FCS)Oct4Sox/Oct motif

Identifiers

PMID29487166
PMCPMC5896025
OpenAlexW2950620706

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.