ArticleScience signaling2018
Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.
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In one paragraph
Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Wnt/CaOncology letters · 2025Review
- Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating (GBA) motif.The Journal of biological chemistry · 2024Review
- Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.Cell reports · 2024Article
- Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer: A focus on biological mechanisms and therapeutic opportunities.World journal of gastroenterology · 2023Review
- Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling?Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin.Tissue engineering and regenerative medicine · 2022Article
- CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia.Journal of cellular and molecular medicine · 2022Article
- A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.Science (New York, N.Y.) · 2021Article
- Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.The Journal of cell biology · 2021Article
- Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Frontiers in molecular neuroscience · 2021Article
- WNT5a in Colorectal Cancer: Research Progress and Challenges.Cancer management and research · 2021Review
- Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2.Journal of cell science · 2020Article
- TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple.Oncogenesis · 2020Article
- Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions.iScience · 2020Article
- Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.Cold Spring Harbor perspectives in medicine · 2020Review
- Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors.Scientific reports · 2019Article
- Wnt Signaling: Pathogen Incursion and Immune Defense.Frontiers in immunology · 2019Review
- FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma.International journal of biological sciences · 2019Article
- Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.Scientific reports · 2018Article
- A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Nicolas AznarDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. nicolas.aznar@inserm.fr prghosh@ucsd.edu.ORCID 0000-0003-3338-9932
Jason EarDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-8580-7748
Ying DunkelDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Nina SunDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Kendall SatterfieldDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-8177-1039
Fang HeDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Nicholas A KalogriopoulosDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Inmaculada Lopez-SanchezDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Majid GhassemianDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Debashis SahooSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Irina KufarevaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9083-7039
Pradipta GhoshDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. nicolas.aznar@inserm.fr prghosh@ucsd.edu.ORCID 0000-0002-8917-3201
University of California San Diego · US
Funding
Spatial Regulation of RGS and G Protein SignalingR01CA100768 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 2003 to 2019
$7.4MAIBP therapyR35HL135737 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY · 2017 to 2023
$6.5MPredoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5MMacromolecular DockingR01GM071872 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ABAGYAN, RUBEN · 2004 to 2017
$4.2MAIBP and regulation of neuropathic painR01NS102432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY, YAKSH, TONY L. · 2017 to 2021
$3.0MThe structural plasticity of chemokine and gp120 recognition by CCR5R01AI118985 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M, KUFAREVA, IRINA · 2015 to 2019
$2.7MChemokine interaction with CXCR4 and ACKR3: structure and activation mechanismsR01GM117424 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M, KUFAREVA, IRINA · 2016 to 2019
$2.2MModulation of G proteins by Growth FactorsR01CA160911 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 2013 to 2017
$1.8MApplication of Boolean Networks to discover stem and progenitor cellsR00CA151673 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2014 to 2016
$717kG Protein pathways as Novel Therapeutic and Diagnostic Targets in Liver FibrosisR01DK099226 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 2014 to 2016
$698kTrimeric G proteins as Novel Targets in Cancer ProgressionF31CA206426 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KALOGRIOPOULOS, NICHOLAS ANTONIOS · 2017 to 2019
$96kNational Cancer Institute F31 CA206426NCI NIH HHS R00 CA151673NCI NIH HHS R01 CA100768NCI NIH HHS R01 CA160911NCI NIH HHS T32 CA067754NHLBI NIH HHS R35 HL135737NIAID NIH HHS R01 AI118985NIDDK NIH HHS R01 DK099226NIGMS NIH HHS R01 GM071872NIGMS NIH HHS R01 GM117424NINDS NIH HHS R01 NS102432
Abstract
Cellular proliferation, differentiation, and morphogenesis are shaped by multiple signaling cascades, and their dysregulation plays an integral role in cancer progression. Three cascades that contribute to oncogenic potential are those mediated by Wnt proteins and the receptor Frizzled (FZD), growth factor receptor tyrosine kinases (RTKs), and heterotrimeric G proteins and associated GPCRs. Daple is a guanine nucleotide exchange factor (GEF) for the G protein G
Indexed as
Colorectal NeoplasmsDishevelled ProteinsFrizzled ReceptorsGene Expression ProfilingGene Expression Regulation, NeoplasticGuanine Nucleotide Exchange FactorsHeLa CellsHeterotrimeric GTP-Binding ProteinsHumansKaplan-Meier EstimatePhosphorylationProtein BindingReceptor Protein-Tyrosine KinasesWnt ProteinsWnt Signaling PathwayDishevelled ProteinsFrizzled ReceptorsGuanine Nucleotide Exchange FactorsHeterotrimeric GTP-Binding ProteinsReceptor Protein-Tyrosine KinasesWnt Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.