Evidence map›Paper›PMID 29492273›Full record

ArticleVirus evolution2016

Rapid Sequencing of Complete

Melissa Laird Smith, Ben Murrell, Kemal Eren, Caroline Ignacio, Elise Landais, Steven Weaver, Pham Phung, Colleen Ludka, Lance Hepler, Gemma Caballero and 8 more

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Long-read amplicon denoising.Nucleic acids research · 2019
    Article
  13. Article
  14. Next-generation sequencing of HIV-1 single genome amplicons.Biomolecular detection and quantification · 2019
    Article
  15. Article
  16. Article
  17. RIFRAF: a frame-resolving consensus algorithm.Bioinformatics (Oxford, England) · 2018
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Melissa Laird SmithPacific Biosciences, Menlo Park, CA, USA.
Ben MurrellPacific Biosciences, Menlo Park, CA, USA.
Kemal ErenPacific Biosciences, Menlo Park, CA, USA.
Caroline IgnacioPacific Biosciences, Menlo Park, CA, USA.
Elise LandaisPacific Biosciences, Menlo Park, CA, USA.
Steven WeaverPacific Biosciences, Menlo Park, CA, USA.
Pham PhungPacific Biosciences, Menlo Park, CA, USA.
Colleen LudkaPacific Biosciences, Menlo Park, CA, USA.
Lance HeplerPacific Biosciences, Menlo Park, CA, USA.
Gemma CaballeroPacific Biosciences, Menlo Park, CA, USA.
Tristan PollnerPacific Biosciences, Menlo Park, CA, USA.
Yan GuoPacific Biosciences, Menlo Park, CA, USA.
Douglas RichmanPacific Biosciences, Menlo Park, CA, USA.
IAVI Protocol C Investigators & The IAVI African HIV Research Network
Pascal PoignardPacific Biosciences, Menlo Park, CA, USA.
Ellen E PaxinosPacific Biosciences, Menlo Park, CA, USA.
Sergei L Kosakovsky PondPacific Biosciences, Menlo Park, CA, USA.
Davey M SmithPacific Biosciences, Menlo Park, CA, USA.
CEA Grenoble · FRCentre National de la Recherche Scientifique · FRPacific Biosciences (United States) · USInstitut de Biologie Structurale · FRScripps Research Institute · USUniversité Grenoble Alpes · FRUniversity of California San Diego · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
High-throughput Deep Sequencing Assay to Reliably Measure the HIV Reservoir during Antiretroviral TherapyR01AI120009 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2015 to 2019
$3.4M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
Viral sequence and dynamic determinants of antibody breadthR00AI120851 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRELL, BENJAMIN SYLVESTER · 2016 to 2017
$493k
Viral sequence and dynamic determinants of antibody breadthK99AI120851 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRELL, BENJAMIN SYLVESTER · 2015 to 2015
$124k
NIAID NIH HHS K24 AI100665NIAID NIH HHS K99 AI120851NIAID NIH HHS P30 AI036214NIAID NIH HHS R00 AI120851NIAID NIH HHS R01 AI120009
6 · The paper itself

Abstract

The ability to study rapidly evolving viral populations has been constrained by the read length of next-generation sequencing approaches and the sampling depth of single-genome amplification methods. Here, we develop and characterize a method using Pacific Biosciences' Single Molecule, Real-Time (SMRT®) sequencing technology to sequence multiple, intact full-length human immunodeficiency virus-1

Indexed as

deep sequencingHIV envelope

Identifiers

PMID29492273
PMCPMC5822884
OpenAlexW2474838662

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.