ReviewInternational journal of molecular sciences2018
Advances in the Genetics of Hypertension: The Effect of Rare Variants.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Combined AGT M235T-ACE I/D genotype and risk of essential hypertension in Vietnamese adults: a hospital-based case-control study.BMC cardiovascular disorders · 2026Article
- Unique clinical features and transcriptomic profiling of carcinogenesis in patients with familial lung cancer in Yunnan Province, Wumeng mountains, China.Respiratory research · 2026Article
- Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing.European journal of pharmacology · 2025Review
- Dietary vitamin intake and its association with hypertension (HPT) among Malaysian adults.Scientific reports · 2025Article
- Unravelling the pathogenesis of Eosinophilic Esophagitis from genetic predisposition to environmental triggers.Clinical and experimental immunology · 2025Review
- Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role ofLife (Basel, Switzerland) · 2025Article
- Digitalization of hypertension management: a paradigm shift.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Prevalence and Factors Associated with Prehypertension and Hypertension Among Adults: Baseline Findings of PURE Malaysia Cohort Study.American journal of medicine open · 2023Article
- An individualized Bayesian method for estimating genomic variants of hypertension.BMC genomics · 2023Article
- Gene-based burden scores identify rare variant associations for 28 blood biomarkers.BMC genomic data · 2023Article
- Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.Journal of the American Heart Association · 2023Article
- A cross-tissue transcriptome association study identifies key genes in essential hypertension.Frontiers in genetics · 2023Article
- G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells.International journal of molecular sciences · 2022Article
- Whole-Genome Sequencing of 100 Genomes Identifies a Distinctive Genetic Susceptibility Profile of Qatari Patients with Hypertension.Journal of personalized medicine · 2022Article
- The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Article
- Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa.African health sciences · 2021Article
- Arterial Hypertension: Individual Therapeutic Approaches-From DNA Sequencing to Gender Differentiation and New Therapeutic Targets.Pharmaceutics · 2021Review
- Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation.Scientific reports · 2021Article
- Association of CHI3L1 gene variants with YKL-40 levels and hypertension incidence: A population-based nested case-control study in China.Journal of cellular and molecular medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, hypertension still represents a serious health burden with nine million people dying as a consequence of hypertension-related complications. Essential hypertension is a complex trait supported by multifactorial genetic inheritance together with environmental factors. The heritability of blood pressure (BP) is estimated to be 30-50%. A great effort was made to find genetic variants affecting BP levels through Genome-Wide Association Studies (GWAS). This approach relies on the "common disease-common variant" hypothesis and led to the identification of multiple genetic variants which explain, in aggregate, only 2-3% of the genetic variance of hypertension. Part of the missing genetic information could be caused by variants too rare to be detected by GWAS. The use of exome chips and Next-Generation Sequencing facilitated the discovery of causative variants. Here, we report the advances in the detection of novel rare variants, genes, and/or pathways through the most promising approaches, and the recent statistical tests that have emerged to handle rare variants. We also discuss the need to further support rare novel variants with replication studies within larger consortia and with deeper functional studies to better understand how new genes might improve patient care and the stratification of the response to antihypertensive treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.