ArticleJournal of the American College of Cardiology2018
Clinical Outcomes in Adolescents and Adults After the Fontan Procedure.
Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07482943 (The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure), which is not on this map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Durable ventricular assist device in adult patients with single ventricle: a systematic literature review.Heart failure reviews · 2024Pooled it
- Body composition in patients with Fontan physiology: a systematic review.European journal of pediatrics · 2023Pooled it
- Impact of Udenafil on Echocardiographic Indices of Single Ventricle Size and Function in FUEL Study Participants.Circulation. Cardiovascular imaging · 2022Trial
- Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis.Pediatric cardiology · 2020Trial
- Results of the FUEL Trial.Circulation · 2020Trial
- Non-Invasive Assessment of Endothelial Dysfunction and Arterial Stiffness in Fontan Circulation.European journal of clinical investigation · 2026Review
- Failing Fontan Following Total Cavopulmonary Connection: Extracardiac Biomarkers Reveal 2 Distinct Phenotypes With Divergent Clinical Courses.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Outcome of Patients with Single Ventricles who Initially did not Indicate Fontan Completion After Stage II Palliation.Pediatric cardiology · 2026Article
- Contemporary Management and Future Directions of Adults Living With a Fontan Circulation.JACC. Advances · 2026Review
- Characteristics Associated with Poor Long-Term Outcomes in Patients with Fontan Palliation: A Case-Control Study.Pediatric cardiology · 2026Article
- Influence of Heart Rate on Hemodynamics in Fontan Circulation.Pediatric cardiology · 2026Article
- Trigger Criteria for Advance-Care Planning in ACHD: The Time Is Now.CJC pediatric and congenital heart disease · 2026Article
- Impact of Nonlinear Heart Rate Variability in Postoperative Complex Congenital Heart Disease: Insights From Repaired Tetralogy of Fallot and Fontan Palliation.Pediatric cardiology · 2026Article
- Cross-Sectional Area Changes in the Total Cavopulmonary Connection Pathway and Its Impact on Liver Fibrosis.Journal of clinical medicine · 2026Article
- Measuring Atrioventricular Valve Regurgitation Using 4D Flow Cardiovascular Magnetic Resonance Post-Fontan.Pediatric cardiology · 2026Article
- Association of Pre-Fontan Hemodynamics With Long-Term Outcomes After Fontan Palliation: A Study From the Pediatric Cardiac Care Consortium.Circulation · 2026Article
- Cardiac Autonomic Function and Atrial Arrhythmias in Adult Patients With a Univentricular Physiology After Fontan Palliation.CJC pediatric and congenital heart disease · 2026Article
- Fontan Route Remodeling over Time: A Longitudinal Quantitative 3D Case Series.Journal of cardiovascular development and disease · 2026Article
- Are Arrhythmias Adequately Incorporated into Studies on Long-Term Outcomes After the Fontan Operation?Pediatric cardiology · 2026Review
- Fontan-Associated Liver Disease (FALD) in the EUROFontan Experience. An Insight into European Awareness.Pediatric cardiology · 2026Observational
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term outcomes of Fontan patients who survive to age ≥16 years have not been well characterized. The Australian and New Zealand Fontan Registry (ANZFR) provides a unique opportunity to understand survival and complication rates in Fontan patients who transition to adult congenital heart disease centers.
objectivesThis study sought to describe the survival and complications of adult patients who have had a Fontan procedure.
methodsThe study analyzed outcomes in patients ≥16 years of age who were prospectively enrolled in the ANZFR.
resultsData from all 683 adult survivors from the ANZFR were analyzed. Mortality status was confirmed from the National Death Index. There were 201 atriopulmonary (AP) connections and 482 total cavopulmonary connections (249 lateral tunnels and 233 extracardiac conduits). For these subjects, the survival rate at age 30 years was 90% (95% CI: 87% to 93%), and it was 80% (95% CI: 75% to 87%) at 40 years of age. Survival at age 30 years was significantly worse for the patients with AP connections (p = 0.03). At latest follow-up, only 53% of patients were in New York Heart Association functional class I. After the age of 16 years, 136 (20%) had experienced at least 1 new arrhythmia, 42 (6%) required a permanent pacemaker, 45 (7%) had a thromboembolic event, and 135 (21%) required a surgical reintervention. Only 41% (95% CI: 33% to 51%) of Fontan patients were free of serious adverse events at 40 years of age.
conclusionsThis comprehensively followed cohort showed that a variety of morbid complications is common in Fontan adults, and that there is a substantial incidence of premature death, particularly in patients with AP connections.
Indexed as
Identifiers
29495980What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.