ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Development of the Mechanisms Governing Midbrain Multisensory Integration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A neuro-computational framework for modeling the development of cross-sensory interactions in Autism: from mechanistic understanding to targeted intervention.Research square · 2026Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Is Competition the Default Configuration of Cross-Sensory Interactions?The European journal of neuroscience · 2025Article
- Unraveling Audiovisual Perception Across Space and Time: A Neuroinspired Computational Architecture.The European journal of neuroscience · 2025Article
- Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration.Medicina (Kaunas, Lithuania) · 2025Review
- Cross-modal exposure restores multisensory enhancement after hemianopia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Noise-rearing precludes the behavioral benefits of multisensory integration.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Association between different sensory modalities based on concurrent time series data obtained by a collaborative reservoir computing model.Scientific reports · 2023Article
- Resolution of impaired multisensory processing in autism and the cost of switching sensory modality.Communications biology · 2022Article
- The brain-body disconnect: A somatic sensory basis for trauma-related disorders.Frontiers in neuroscience · 2022Review
- Learning multisensory cue integration: A computational model of crossmodal synaptic plasticity enables reliability-based cue weighting by capturing stimulus statistics.Frontiers in neural circuits · 2022Article
- Wired to Connect: The Autonomic Socioemotional Reflex Arc.Frontiers in psychology · 2022Review
- Orienting our view of the superior colliculus: specializations and general functions.Current opinion in neurobiology · 2021Review
- Neuroplasticity and Crossmodal Connectivity in the Normal, Healthy Brain.Psychology & neuroscience · 2021Article
- Editorial: Sensory Processing Across the Lifespan: A 25-Year Initiative to Understand Neurophysiology, Behaviors, and Treatment Effectiveness for Sensory Processing.Frontiers in integrative neuroscience · 2021Article
- Using the Principles of Multisensory Integration to Reverse Hemianopia.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Experience Creates the Multisensory Transform in the Superior Colliculus.Frontiers in integrative neuroscience · 2020Article
- Cross-Modal Competition: The Default Computation for Multisensory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Integration of visual and whisker signals in rat superior colliculus.Scientific reports · 2018Article
- Evidence for Brainstem Contributions to Autism Spectrum Disorders.Frontiers in integrative neuroscience · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ability to integrate information across multiple senses enhances the brain's ability to detect, localize, and identify external events. This process has been well documented in single neurons in the superior colliculus (SC), which synthesize concordant combinations of visual, auditory, and/or somatosensory signals to enhance the vigor of their responses. This increases the physiological salience of crossmodal events and, in turn, the speed and accuracy of SC-mediated behavioral responses to them. However, this capability is not an innate feature of the circuit and only develops postnatally after the animal acquires sufficient experience with covariant crossmodal events to form links between their modality-specific components. Of critical importance in this process are tectopetal influences from association cortex. Recent findings suggest that, despite its intuitive appeal, a simple generic associative rule cannot explain how this circuit develops its ability to integrate those crossmodal inputs to produce enhanced multisensory responses. The present neurocomputational model explains how this development can be understood as a transition from a default state in which crossmodal SC inputs interact competitively to one in which they interact cooperatively. Crucial to this transition is the operation of a learning rule requiring coactivation among tectopetal afferents for engagement. The model successfully replicates findings of multisensory development in normal cats and cats of either sex reared with special experience. In doing so, it explains how the cortico-SC projections can use crossmodal experience to craft the multisensory integration capabilities of the SC and adapt them to the environment in which they will be used.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.