ArticleScientific reports2018
Association between homocysteine and conventional predisposing factors on risk of stroke in patients with hypertension.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Prevalence and clinical correlates of hyperhomocysteinemia in Chinese urban population with hypertension.Frontiers in endocrinology · 2024Article
- H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China.BMC cardiovascular disorders · 2023Article
- MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate.Journal of clinical medicine · 2022Article
- Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound.Journal of atherosclerosis and thrombosis · 2022Article
- Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- An Online Pre-procedural Nomogram for the Prediction of Contrast-Associated Acute Kidney Injury in Patients Undergoing Coronary Angiography.Frontiers in medicine · 2022Article
- Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China.International journal of hypertension · 2022Article
- Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018.Frontiers of medicine · 2021Article
- Homocysteine, hypertension, and risks of cardiovascular events and all-cause death in the Chinese elderly population: a prospective study.Journal of geriatric cardiology : JGC · 2021Article
- The association between retinal vessel abnormalities and H-type hypertension.BMC neurology · 2021Article
- Corn Silk Tea for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Association between plasma homocysteine and hypertension: Results from a cross-sectional and longitudinal analysis in Beijing's adult population from 2012 to 2017.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have focused mostly on independent effects of the stroke risk factors, whereas little attention has been paid to interactions between individual factors which may be important for stroke prevention. We collected data related to the patients' demographic characteristics, history of chronic diseases and lifestyle factors in 2258 patients with primary hypertension. Logistic regression models based on odds ratio (OR) with their associated 95% confidence interval (CI) were used to estimate an independent effect of homocysteine (Hcy) on the risk of stroke but also include the interactions between Hcy and other risk factors. Hcy was associated with an increased OR of the risk of stroke in both hypertension patients (OR, 1.027; 95% CI, 1.016-1.038; P < 0.001) and H-type hypertension patients (OR, 1.026; 95% CI, 1.014-1.037; P < 0.001), after adjustment for potential confounding factors. Among the hypertension participants, three tests of interactions between Hcy and other risk factors were statistically significant: sex, systolic blood pressure and diastolic blood pressure. In conclusion, complexities of the interactions of Hcy stratified by sex and blood pressure need to be considered in predicting overall risk and selecting certain treatments for stroke prevention.
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