Evidence map›Paper›PMID 29504647›Full record

ArticleAddiction biology2019

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats.

Craig P Allen, Kicheon Park, Ang Li, Nora D Volkow, George F Koob, Yingtian Pan, Xiu-Ti Hu, Congwu Du

Open access · greenAbstract read
In one paragraph

Article in Addiction biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  13. CaTranslational psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Craig P AllenDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0001-8370-3884
Kicheon ParkDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Ang LiDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
George F KoobNational Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Yingtian PanDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Xiu-Ti HuDepartment of Immunology and Microbiology, Rush University Medical Center, Chicago, Il, USA.
Congwu DuDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Stony Brook University · USNational Institutes of Health · USRush University Medical Center · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Calcium-related Neurotoxicity of CocaineR01DA029718 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DU, CONGWU, PAN, YINGTIAN · 2012 to 2025
$4.2M
Interactive effects of Meth, HIV and cART on astrocyte/neuron functionR01DA044552 · NIDA · RUSH UNIVERSITY MEDICAL CENTER · PI HU, XIU-TI · 2017 to 2021
$2.9M
Electrophysiological mechanisms of HIV-mediated neuropathogenesisR01NS084817 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI HU, XIU-TI · 2013 to 2017
$2.5M
Cortical pathophysiology in cocaine sef-administering HIV-1 transgenic ratsR21DA033882 · NIDA · RUSH UNIVERSITY MEDICAL CENTER · PI HU, XIU-TI, NAPIER, T. CELESTE · 2012 to 2013
$412k
Optical platform to image neuronal and vascular effects of cocaine in awake rodentsR21DA042597 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DU, CONGWU, PAN, YINGTIAN · 2016 to 2017
$392k
NIDA NIH HHS R01 DA029718NIDA NIH HHS R01 DA044552NIDA NIH HHS R21 DA033882NIDA NIH HHS R21 DA042597NIH's Intramural Program of NIAAANINDS NIH HHS R01 NS084817
6 · The paper itself

Abstract

Cocaine addiction is associated with dysfunction of the prefrontal cortex (PFC), which facilitates relapse and compulsive drug taking. To assess if cocaine's effects on both neuronal and vascular activity contribute to PFC dysfunction, we used optical coherence tomography and multi-wavelength laser speckle to measure vascularization and hemodynamics and used GCaMP6f to monitor intracellular Ca

Indexed as

Anesthetics, InhalationAnimalsCerebrovascular CirculationCocaineConditioning, OperantDopamine Uptake InhibitorsHemodynamicsHemoglobinsIsofluraneMaleNeuroimagingNeuronsPrefrontal CortexRats, Sprague-DawleySelf AdministrationTomography, Optical CoherenceAnesthetics, InhalationCocaineDopamine Uptake InhibitorsHemoglobinsIsofluraneaddictionhemodynamicsintracellular calciumprefrontal cortexself-administration

Identifiers

PMID29504647
PMCPMC6123312
OpenAlexW2790819691

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.