Evidence map›Paper›PMID 29504901›Full record

ArticleBMC genomics2018

Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats.

Natalia A Stefanova, Kseniya Yi Maksimova, Ekaterina A Rudnitskaya, Natalia A Muraleva, Nataliya G Kolosova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalia A StefanovaInstitute of Cytology and Genetics, Novosibirsk, Russia. stefanovan@mail.ru.
Kseniya Yi MaksimovaInstitute of Cytology and Genetics, Novosibirsk, Russia.
Ekaterina A RudnitskayaInstitute of Cytology and Genetics, Novosibirsk, Russia.
Natalia A MuralevaInstitute of Cytology and Genetics, Novosibirsk, Russia.
Nataliya G KolosovaInstitute of Cytology and Genetics, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebrovascular dysfunction plays a critical role in the pathogenesis of Alzheimer's disease (AD): the most common cause of dementia in the elderly. The involvement of neurovasculature disorders in the progression of AD is now increasingly appreciated, but whether they represent initial factors or late-stage pathological changes during the disease is unclear. Using senescence-accelerated OXYS rats, which simulate key characteristics of sporadic AD, we evaluated contributions of cerebrovascular alterations to the disease development. At preclinical, early, and advanced stages of AD-like pathology, in the hippocampus of OXYS and Wistar (control) rats, we evaluated (i) the blood vessel state by histological and electron-microscopic analyses; (ii) differences in gene expression according to RNA sequencing (RNA-Seq) to identify the metabolic processes and pathways associated with blood vessel function; (iii) the amount of vascular endothelial growth factor (VEGF) by western blot and immunohistochemical analysis.

resultsWe observed a loss of hippocampal blood vessel density and ultrastructural changes of those blood vessels in OXYS rats at the early stage of AD-like pathology. There were significant alterations in the vessels and downregulation of VEGF with an increased amount of amyloid β

conclusionsChanges in expression of the genes functionally associated with cerebrovascular processes already in the early period of life may contribute to the development of AD-like pathology in OXYS rats.

Indexed as

AgingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBlood VesselsGene Expression ProfilingGene Regulatory NetworksHippocampusMolecular Sequence AnnotationPeptide FragmentsRatsSpecies SpecificityVascular Endothelial Growth Factor AAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsVascular Endothelial Growth Factor AAlzheimer’s diseaseCerebrovascular dysfunctionOXYS ratsRNA sequencing

Identifiers

PMID29504901
PMCPMC5836823

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.