Evidence map›Paper›PMID 29506013›Full record

Trial reportNeuroendocrinology2018

Influence of Sleep Stage on LH Pulse Initiation in the Normal Late Follicular Phase and in Polycystic Ovary Syndrome.

Christine Lu, Eleanor G Hutchens, Leon S Farhy, Heather G Bonner, Paul M Suratt, Christopher R McCartney

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. The Menstrual Cycle and Sleep.Sleep medicine clinics · 2023
    Review
  3. Sleep and Puberty.Current opinion in endocrine and metabolic research · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Abnormal GnRH Pulsatility in Polycystic Ovary Syndrome: Recent Insights.Current opinion in endocrine and metabolic research · 2020 · on this map
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christine LuUniversity of Virginia School of Medicine, Charlottesville, Virginia, USA.
Eleanor G HutchensDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Leon S FarhyDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Heather G BonnerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Paul M SurattDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Christopher R McCartneyDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
University of Virginia · US

Funding

PROJECT 3 - Steroid-Metabolic Interactions In the Control of GnRH NeuronsU54HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SHUPNIK, MARGARET A · 1998 to 2013
$16.5M
Testosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6M
Research Training in Neuroendocrinology and MetabolismT32DK007646 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZHENQI LIU · 1990 to 2026
$4.9M
Insulin-Glucose-Glucagon Network: Defining a type 1 diabetes progression modelDP3DK106907 · NIDDK · UNIVERSITY OF VIRGINIA · PI BROWN, SUE A, FARHI, LEON S · 2015 to 2015
$1.5M
Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOSR01HD058671 · NICHD · UNIVERSITY OF VIRGINIA · PI MCCARTNEY, CHRISTOPHER ROLLAND · 2008 to 2012
$1.2M
NICHD NIH HHS P50 HD028934NICHD NIH HHS R01 HD058671NICHD NIH HHS U54 HD028934NIDDK NIH HHS DP3 DK106907NIDDK NIH HHS T32 DK007646NIH HHS DP3 DK106907NIH HHS R01 HD058671NIH HHS R01 HD058671-02S1NIH HHS T32 DK07646NIH HHS U54 HD28934
6 · The paper itself

Abstract

objectiveDuring the early follicular phase, sleep-related luteinizing hormone (LH) pulse initiation is positively associated with brief awakenings but negatively associated with rapid eye movement (REM) sleep. The relationship between sleep architecture and LH pulse initiation has not been assessed in other cycle stages or in women with polycystic ovary syndrome (PCOS). DESIGN AND

methodsWe performed concomitant frequent blood sampling (LH pulse analysis) and polysomnography on 8 normal women (cycle day 7-11) and 7 women with PCOS (at least cycle day 7).

resultsIn the normal women, the 5 min preceding LH pulses contained more wake epochs and fewer REM epochs than the 5 min preceding randomly determined time points (wake: 22.3 vs. 9.1%, p = 0.0111; REM: 4.4 vs. 18.8%, p = 0.0162). However, LH pulse initiation was not related to wake or REM epochs in PCOS; instead, the 5 min preceding LH pulses contained more slow-wave sleep (SWS) than the 5 min before random time points (20.9 vs. 6.7%, p = 0.0089). Compared to the normal subjects, the women with PCOS exhibited a higher REM-associated LH pulse frequency (p = 0.0443) and a lower proportion of wake epochs 0-5 min before LH pulses (p = 0.0205).

conclusionsSleep-related inhibition of LH pulse generation during the later follicular phase is normally weakened by brief awakenings and strengthened by REM sleep. In women with PCOS, LH pulse initiation is not appropriately discouraged by REM sleep and may be encouraged by SWS; these abnormalities may contribute to a high sleep-related LH pulse frequency in PCOS.

Indexed as

AdultAndrogen AntagonistsCross-Over StudiesEstradiolFemaleFlutamideFollicular PhaseHumansLuteinizing HormonePolycystic Ovary SyndromeProgesteroneSleep StagesYoung AdultAndrogen AntagonistsEstradiolFlutamideLuteinizing HormoneProgesteroneGonadotropin-releasing hormoneLuteinizing hormonePolycystic ovary syndromeSleep

Identifiers

PMID29506013
PMCPMC7053660
OpenAlexW2793527226

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.