ReviewInternational journal of molecular sciences2018
Caloric Restriction and Its Effect on Blood Pressure, Heart Rate Variability and Arterial Stiffness and Dilatation: A Review of the Evidence.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- The Effect of Non-Oil Seed Legume Intake on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Trial
- Effects of different aerobic exercise programs on cardiac autonomic modulation and hemodynamics in hypertension: data from EXERDIET-HTA randomized trial.Journal of human hypertension · 2020Trial
- Trial
- Nitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction.The Journal of clinical investigation · 2026Article
- The higher dietary energy-to-fiber ratio is associated with an increased risk of poor blood pressure control among patients with essential hypertension: a cross-sectional study.Frontiers in nutrition · 2026Article
- Reactivity of Isolated Arteries After 5-Week-Lasting Period of Intermittent Fasting Followed by the Return to Ad Libitum Regimen in Healthy Rats Fed With Normal and High-Fat Diet.Physiological research · 2025Article
- An Effective Microcurrent Stimulation Method for Inducing Non-Pharmacological Parasympathetic Nervous System Activity for Pain Relief.Bioengineering (Basel, Switzerland) · 2025Article
- Traditional Health Practices May Promote Nrf2 Activation Similar to Exercise.International journal of molecular sciences · 2025Review
- Effectiveness of Roux-en-Y Gastric Bypass Versus Hypocaloric Diet in Reducing Cardiovascular Risk Factors in Obese Adults: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Sodium-glucose cotransporter 2 inhibitors for hypertension in cardiovascular-kidney-metabolic syndrome.Experimental physiology · 2025Review
- Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.Signal transduction and targeted therapy · 2025Review
- Impact of cardiometabolic risk factors and its management on the reversion and progression of arterial stiffness.NPJ cardiovascular health · 2025Review
- Exploring the Impact of Intermittent Fasting on Vascular Function and the Immune System: A Narrative Review and Novel Perspective.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Heart rate variability and its modulation by nutrients: a narrative review on implications for cardiovascular aging.Frontiers in neuroscience · 2025Review
- Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.Physiological measurement · 2024Review
- Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport.Cell metabolism · 2024Article
- Caloric restriction reduces proteinuria in male rats with established nephropathy.Physiological reports · 2024Article
- Association between lifestyle factors and hypertension control in Indonesian primary healthcare settings: A cross-sectional study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2024Article
- Obesity and hypertension: Obesity medicine association (OMA) clinical practice statement (CPS) 2023.Obesity pillars · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential hypertension, fast heart rate, low heart rate variability, sympathetic nervous system dominance over parasympathetic, arterial stiffness, endothelial dysfunction and poor flow-mediated arterial dilatation are all associated with cardiovascular mortality and morbidity. This review of randomised controlled trials and other studies demonstrates that caloric restriction (CR) is capable of significantly improving all these parameters, normalising blood pressure (BP) and allowing patients to discontinue antihypertensive medication, while never becoming hypotensive. CR appears to be effective regardless of age, gender, ethnicity, weight, body mass index (BMI) or a diagnosis of metabolic syndrome or type 2 diabetes, but the greatest benefit is usually observed in the sickest subjects and BP may continue to improve during the refeeding period. Exercise enhances the effects of CR only in hypertensive subjects. There is as yet no consensus on the mechanism of effect of CR and it may be multifactorial. Several studies have suggested that improvement in BP is related to improvement in insulin sensitivity, as well as increased nitric oxide production through improved endothelial function. In addition, CR is known to induce SIRT1, a nutrient sensor, which is linked to a number of beneficial effects in the body.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.