← Statins × cardiovascular events

TrialJAMA2018

Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial.

Otavio Berwanger et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 4,191 people · 2018

Range includes no effect

No clear effect on cardiovascular events

+0.85percentage points−0.70 to +2.41

As reported

difference 0.85 %, 95% CI −0.70 to 2.41

Range includes no effect

No clear effect on cardiovascular events

−12%−31% to +11%

6 in 100 instead of 7

Bigger than 2 in 10 for cardiovascular events

As reported

HR 0.88, 95% CI 0.69–1.11

Two numbers in the abstract

the abstract, start to end

… (7.1%) had a MACE (absolute difference, 0.85% [95% CI, -0.70% to 2.41%]; hazard ratio, 0.88; 95% CI, 0.69-1.11; P = .27).

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
0.85−0.70 to 2.41
Cardiovascular events
HR 0.880.69–1.11
StatinsCardiovascular events

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.860.86 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 5

65 papers cite itlatest 60 shown

2018
2019
2020
2021
2022
2023
2024
2025
this paperpooled ittrialcites it

The trial

NCT01448642phase 44,191 enrolled2012
Full record →Abstract, authors, funding and every citing paper · PMID 29525821