Evidence map›Paper›PMID 29525920›Full record

ArticleEating and weight disorders : EWD2020

Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS).

Bahareh Sedaghati-Khayat, Maryam Barzin, Mahdi Akbarzadeh, Kamran Guity, Mohammad-Sadegh Fallah, Hoda Pourhassan, Fereidoun Azizi, Maryam S Daneshpour

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Article in Eating and weight disorders : EWD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
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  6. Association of fat mass and obesity-associated (Journal of diabetes and metabolic disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Bahareh Sedaghati-KhayatCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19195-4763, Tehran, Islamic Republic of Iran.
Maryam BarzinObesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mahdi AkbarzadehCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19195-4763, Tehran, Islamic Republic of Iran.
Kamran GuityCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19195-4763, Tehran, Islamic Republic of Iran.
Mohammad-Sadegh FallahKawsar Human Genetics Research Center, Tehran, Islamic Republic of Iran.
Hoda PourhassanDepartment of Internal Medicine, University of California Riverside, Riverside, CA, USA.
Fereidoun AziziEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Maryam S DaneshpourCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19195-4763, Tehran, Islamic Republic of Iran. daneshpour@sbmu.ac.ir.
Shahid Beheshti University of Medical Sciences · IRKowsar Hospital · IRUniversity of California, Riverside · US

Funding

Iran National Scientific Foundation 93017278
6 · The paper itself

Abstract

backgroundObesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes. MATERIALS AND

methodsWe selected 954 adult subjects from TCGS (47.9% male). Participants were stratified according to their BMI and presence of metabolic syndrome according to the Joint Interim Statement (JIS) definition. Nine selected polymorphisms from FTO/CETP genes were genotyped using Tetra ARMS-PCR method. After age and sex adjustment the interaction of 9 markers with lipid profiles among phenotypes were tested by PASW.

resultsIn three main groups, HDL_C level had a strong significant association with CETP markers: (rs3764261, β(95% CI) - 0.48(- 0.61 to - 0.35), P = 1.0 × 10

conclusionIn the present study, we investigated the association between obesity phenotypes and some variations in FTO/CETP genes for the first time. Our study showed that four markers in the first intron of the FTO gene should be the risk marker in MUHO participants. LEVEL OF EVIDENCE: Level III, case-control study.

Indexed as

GenotypePolymorphism, Single NucleotideAdultAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOBlood GlucoseCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansLipidsMaleMiddle AgedObesity, Metabolically BenignPhenotypeAlpha-Ketoglutarate-Dependent Dioxygenase FTOBlood GlucoseFTO protein, humanLipidsCholesteryl ester transfer proteinFat mass and obesity-associated proteinMetabolic syndromeObesity

Identifiers

PMID29525920
OpenAlexW2792952843

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.