SynthesisPloS one2018
A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04043780 (Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome: a Multicentric Randomized Controlled Trial
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Effects of Orthotic Interventions on Pain, Balance, and Plantar Pressure in Flexible Flatfoot: A Systematic Review.Journal of foot and ankle research · 2026Pooled it
- The 2026 British Society for Rheumatology guideline for pain management in people with inflammatory arthritis.Rheumatology (Oxford, England) · 2026Guideline
- Adjustable prosthetic sockets: a systematic review of industrial and research design characteristics and their justifications.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Technology for monitoring everyday prosthesis use: a systematic review.Journal of neuroengineering and rehabilitation · 2020Pooled it
- Trial
- Protective Equipment in Football: A Review of History, Evolution, Materials, and Contemporary Use.Sports (Basel, Switzerland) · 2025Review
- Footwear Choice and Locomotor Health Throughout the Life Course: A Critical Review.Healthcare (Basel, Switzerland) · 2025Review
- Effects of trimline cut in ankle foot orthosis: An experimental and finite element analysis.Journal of orthopaedics · 2024Article
- Effect of knee bracing on clinical outcomes following anterior cruciate ligament reconstruction: A prospective randomised controlled study.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2024Article
- Article
- Enhancing Functional Rehabilitation Through Orthotic Interventions for Foot and Ankle Conditions: A Narrative Review.Cureus · 2023Review
- Upper limb practice with a dynamic hand orthosis to improve arm and hand function in people after stroke: a feasibility study.Pilot and feasibility studies · 2023Article
- Criteria for Advanced Prosthetic Foot Prescription: Rationale, Design, and Protocol for a Multisite, Randomized Controlled Trial.JMIR research protocols · 2023Article
- Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Improving Physical, Physiological, and Psychological Health Outcomes in Patients with Diabetic Foot Ulcers - State of the Art.Clinical, cosmetic and investigational dermatology · 2023Review
- Effects of specialist care lower limb orthoses on personal goal attainment and walking ability in adults with neuromuscular disorders.PloS one · 2023Article
- Carpal tunnel syndrome conservative treatment: a literature review.Postepy psychiatrii neurologii · 2022Review
- Patient Compliance With Wearing Lower Limb Assistive Devices: A Scoping Review.Journal of manipulative and physiological therapeutics · 2022Article
- A Systematic Review of Systematic Reviews on the Epidemiology, Evaluation, and Treatment of Plantar Fasciitis.Life (Basel, Switzerland) · 2021Review
- Effect of Ankle Torque on the Ankle-Foot Orthosis Joint Design Sustainability.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssistive products are items which allow older people and people with disabilities to be able to live a healthy, productive and dignified life. It has been estimated that approximately 1.5% of the world's population need a prosthesis or orthosis.
objectiveThe objective of this study was to systematically identify and review the evidence from randomized controlled trials assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions.
methodsLiterature searches, completed in September 2015, were carried out in fourteen databases between years 1995 and 2015. The search results were independently screened by two reviewers. For the purpose of this manuscript, only randomized controlled trials which examined interventions using orthotic or prosthetic devices were selected for data extraction and synthesis.
resultsA total of 342 randomised controlled trials were identified (319 English language and 23 non-English language). Only 4 of these randomised controlled trials examined prosthetic interventions and the rest examined orthotic interventions. These orthotic interventions were categorised based on the medical conditions/injuries of the participants. From these studies, this review focused on the medical condition/injuries with the highest number of randomised controlled trials (osteoarthritis, fracture, stroke, carpal tunnel syndrome, plantar fasciitis, anterior cruciate ligament, diabetic foot, rheumatoid and juvenile idiopathic arthritis, ankle sprain, cerebral palsy, lateral epicondylitis and low back pain). The included articles were assessed for risk of bias using the Cochrane Risk of Bias tool. Details of the clinical population examined, the type of orthotic/prosthetic intervention, the comparator/s and the outcome measures were extracted. Effect sizes and odds ratios were calculated for all outcome measures, where possible.
conclusionsAt present, for prosthetic and orthotic interventions, the scientific literature does not provide sufficient high quality research to allow strong conclusions on their effectiveness and cost-effectiveness.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.