ArticleBrain, behavior, and immunity2018
Minority stress and leukocyte gene expression in sexual minority men living with treated HIV infection.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- The relationship between minority stress and biological outcomes: A systematic review.Journal of behavioral medicine · 2020Pooled it
- Differential gene expression in response to AWARENESS: A randomized controlled trial of an intersectional minority stress intervention.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Trial
- Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.Brain, behavior, and immunity · 2018Trial
- Post-traumatic stress disorder and adverse pregnancy outcomes: sexual orientation disparities in a prospective cohort study.BMC pregnancy and childbirth · 2026Article
- Sexual minority adults exhibit greater inflammation than heterosexual adults in the context of depressive symptoms and anxiety: Pathways to health disparities.Brain, behavior, and immunity · 2026Article
- Body talk: Correlates of gut-immune dysregulation phenotypes in people living with HIV who use methamphetamine.Brain, behavior, & immunity - health · 2026Article
- Latino Sexual Minority Men Living with HIV in South Florida have Varied Experiences of Intersectional Discrimination: A Mixed Methods Pilot Study.AIDS and behavior · 2025Article
- LGBTQ+ identity and its association with inflammation and cellular immune function.Brain, behavior, and immunity · 2025Article
- Cancer disparities by age: a focus on sexual and gender minorities.Cancer causes & control : CCC · 2025Article
- The Association between Childhood Adversity and the Conserved Transcriptional Response to Adversity (CTRA) in Sexual Minority Men.Journal of child & adolescent trauma · 2025Article
- Trauma Symptoms, Minority Stress, and Substance Use: Implications for Trauma Treatment in Sexual and Gender Minority Communities.Psychology of sexual orientation and gender diversity · 2025Article
- Structural Determinants of Health and Markers of Immune Activation and Systemic Inflammation in Sexual Minority Men With and Without HIV.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
- Acceptability of Biospecimen Collection Among Sexual and/or Gender Minority Adults in the United States.Annals of LGBTQ public and population health · 2023Article
- Effects of Bullying on Anxiety, Depression, and Posttraumatic Stress Disorder Among Sexual Minority Youths: Network Analysis.JMIR public health and surveillance · 2023Article
- Stimulant use, HIV, and immune dysregulation among sexual minority men.Drug and alcohol dependence · 2023Article
- Conceptualizing the Mechanisms of Social Determinants of Health: A Heuristic Framework to Inform Future Directions for Mitigation.The Milbank quarterly · 2023Review
- Human genes with relative synonymous codon usage analogous to that of polyomaviruses are involved in the mechanism of polyomavirus nephropathy.Frontiers in cellular and infection microbiology · 2022Article
- A biopsychosocial framework for understanding sexual and gender minority health: A call for action.Neuroscience and biobehavioral reviews · 2021Review
- Propensity Score Analysis Assessing the Burden of Non-Communicable Diseases among the Transgender Population in the United States Using the Behavioral Risk Factor Surveillance System (2017-2019).Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Sexual minority (i.e., non-heterosexual) individuals experience poorer mental and physical health, accounted for in part by the additional burden of sexual minority stress occurring from being situated in a culture favoring heteronormativity. Informed by previous research, the purpose of this study was to identify the relationship between sexual minority stress and leukocyte gene expression related to inflammation, cancer, immune function, and cardiovascular function. Sexual minority men living with HIV who were on anti-retroviral medication, had viral load < 200 copies/mL, and had biologically confirmed, recent methamphetamine use completed minority stress measures and submitted blood samples for RNA sequencing on leukocytes. Differential gene expression and pathway analyses were conducted comparing those with clinically elevated minority stress (n = 18) and those who did not meet the clinical cutoff (n = 20), covarying reactive urine toxicology results for very recent stimulant use. In total, 90 differentially expressed genes and 138 gene set pathways evidencing 2-directional perturbation were observed at false discovery rate (FDR) < 0.10. Of these, 41 of the differentially expressed genes and 35 of the 2-directionally perturbed pathways were identified as functionally related to hypothesized mechanisms of inflammation, cancer, immune function, and cardiovascular function. The neuroactive-ligand receptor pathway (implicated in cancer development) was identified using signaling pathway impact analysis. Our results suggest several potential biological pathways for future work investigating the relationship between sexual minority stress and health.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.