Evidence map›Paper›PMID 29549354›Full record

ReviewNutrition & diabetes2018

The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED.

Hayley E Billingsley, Salvatore Carbone

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition & diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07022782 (A Nutritional Intervention Based on the Principles of Mediterranean Diet as a Putative Regulator of Craving and Redox Status of Patients Under Medication-assisted Treatment With Methadone and Buprenorphine), which is not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07022782 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

A Nutritional Intervention Based on the Principles of Mediterranean Diet as a Putative Regulator of Craving and Redox Status of Patients Under Medication-assisted Treatment With Methadone and Buprenorphine: The Study Protocol of a Randomized Controlled Trial (the MED-DOPE Study)

TypeinterventionalSponsorAristidis VeskoukisRan2025 to 2026Enrolled40ConditionsOpioid AddictionArmsA nutritional intervention based on the principles of Mediterranean diet
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Trial
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  7. Article
  8. The Oxidative Stress: Origin and Role in Aging and Diseases.Antioxidants (Basel, Switzerland) · 2026
    Review
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  19. Article
  20. Navigating Cardiovascular Challenges of Obesity: Exploring Preventive Approaches.Endocrine, metabolic & immune disorders drug targets · 2025
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hayley E BillingsleyVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Salvatore CarboneVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA. salvatore.carbone@vcuhealth.org.ORCID http://orcid.org/0000-0002-8163-0527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols. Subgroup analysis of the PREDIMED trial revealed increased endogenous antioxidant and decreased pro-oxidant activity in the MedDiet groups. Moreover, higher polyphenol intake was associated with lower incidence of the primary outcome, overall mortality, blood pressure, inflammatory biomarkers, onset of new-onset type 2 diabetes mellitus (T2DM), and obesity. This suggests that polyphenols likely contributed to the lower incidence of the primary event in the MedDiet groups. In this article, we summarize the potential benefits of polyphenols found in the MedDiet, specifically the PREDIMED cohort. We also discuss the need for further research to confirm and expand the findings of the PREDIMED in a non-Mediterranean population and to determine the exact mechanisms of action of polyphenols.

Indexed as

Diet, MediterraneanAntioxidantsBlood PressureCardiovascular DiseasesCohort StudiesDiabetes Mellitus, Type 2HumansInflammation MediatorsObesityOxidative StressPlant ExtractsPolyphenolsAntioxidantsInflammation MediatorsPlant ExtractsPolyphenols

Identifiers

PMID29549354
PMCPMC5856841

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.