Evidence map›Paper›PMID 29550970›Full record

ArticleJournal of genetic counseling2018

Factors Influencing Clinical Follow-Up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Uninformative BRCA1 and BRCA2 Testing.

Sarah E Chadwell, Hua He, Sara Knapke, Jaime Lewis, Rebecca Sisson, Jennifer Hopper

Abstract read
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Article in Journal of genetic counseling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah E ChadwellGenetic Counseling Program, College of Medicine, University of Cincinnati and Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue ML 4006, Cincinnati, OH, 45229, USA. Sarah.Chadwell@cchmc.org.
Hua HeDivision of Human Genetics, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Sara KnapkeInherited Cancer, GeneDx, Gaithersburg, MD, USA.
Jaime LewisDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rebecca SissonDivision of Human Genetics, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Jennifer HopperDivision of Human Genetics, Cincinnati Children's Hospital, Cincinnati, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic testing for inherited cancer risk has recently improved through the advent of multi-gene panels and the addition of deletion and duplication analysis of the BRCA genes. The primary aim of this study was to determine which factors influence the intent of individuals with a personal history of breast and/or ovarian cancer and negative or uncertain BRCA1 and BRCA2 testing to return to a hereditary cancer program for additional genetic risk assessment, counseling, and testing. Surveys were sent to 1197 individuals and 257 were returned. Of those participants who were planning to return to clinic, most cited having family members who could benefit from the test result as the primary motivation to return. Many participants who were not planning to return to clinic cited the cost of testing as a barrier to return. Cost of testing and concerns about insurance coverage were the most commonly cited barriers for the group of participants who were undecided about returning to clinic. Results from this study may be used to guide re-contact efforts by clinicians to increase patient uptake to return to clinic for up-to-date genetic risk assessment, counseling, and testing.

Indexed as

Genes, BRCA1Genes, BRCA2AdultBreast NeoplasmsFemaleFollow-Up StudiesGenetic TestingHumansMiddle AgedOvarian NeoplasmsRisk FactorsBarriersBRCA negativeBreast cancerGenetic testingHereditary cancerMotivationsMulti-gene panel testingOvarian cancerReturn behavior

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.