Evidence map›Paper›PMID 29559522›Full record

ArticleJournal of lipid research2018

AIBP protects against metabolic abnormalities and atherosclerosis.

Dina A Schneider, Soo-Ho Choi, Colin Agatisa-Boyle, Laurence Zhu, Jungsu Kim, Jennifer Pattison, Dorothy D Sears, Philip L S M Gordts, Longhou Fang, Yury I Miller

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

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  6. Restoring AIBP expression in the retina provides neuroprotection in glaucoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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  18. Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dina A SchneiderDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.ORCID 0000-0002-5276-3304
Soo-Ho ChoiDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Colin Agatisa-BoyleDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Laurence ZhuCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030.
Jungsu KimDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Jennifer PattisonDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Dorothy D SearsDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Philip L S M GordtsDepartments of Medicine University of California at San Diego, La Jolla, CA 92093.
Longhou FangCenter for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030.
Yury I MillerDepartments of Medicine University of California at San Diego, La Jolla, CA 92093 yumiller@ucsd.edu.
University of California San Diego · USHouston Methodist · US

Funding

Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2008 to 2018
$26.4M
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
AIBP therapyR35HL135737 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY · 2017 to 2023
$6.5M
EXPERIMENTAL ENDOCRINOLOGY AND METABOLISMT32DK007044 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Amit Majithia · 1986 to 2026
$4.6M
AIBP Mediates a Novel Interplay between Cholesterol Metabolism and LymphangiogenesisR01HL132155 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI FANG, LONGHOU · 2016 to 2020
$2.7M
AIBP-Mediated Cholesterol Efflux and AngiogenesisR00HL114734 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI FANG, LONGHOU · 2015 to 2017
$738k
AIBP-Mediated Cholesterol Efflux and AngiogenesisK99HL114734 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, LONGHOU · 2012 to 2013
$238k
NHLBI NIH HHS K99 HL114734NHLBI NIH HHS P01 HL088093NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R00 HL114734NHLBI NIH HHS R01 HL132155NHLBI NIH HHS R35 HL135737NIDDK NIH HHS T32 DK007044
6 · The paper itself

Abstract

Apolipoprotein A-I binding protein (AIBP) has been shown to augment cholesterol efflux from endothelial cells and macrophages. In zebrafish and mice, AIBP-mediated regulation of cholesterol levels in the plasma membrane of endothelial cells controls angiogenesis. The goal of this work was to evaluate metabolic changes and atherosclerosis in AIBP loss-of-function and gain-of-function animal studies. Here, we show that

Indexed as

AnimalsAtherosclerosisCarrier ProteinsInflammationLipopolysaccharidesMetabolic SyndromeMiceMice, Inbred C57BLMice, KnockoutPhosphoproteinsRacemases and EpimerasesReceptors, LDLCarrier ProteinsLipopolysaccharidesNaxe protein, mousePhosphoproteinsRacemases and EpimerasesReceptors, LDLhepatosteatosishypercholesterolemiahypertriglyceridemialipid rafts

Identifiers

PMID29559522
PMCPMC5928435
OpenAlexW2789511061

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.