Evidence map›Paper›PMID 29562783›Full record

ArticleCell transplantation2018

Wharton's Jelly Mesenchymal Stromal Cells Support the Expansion of Cord Blood-derived CD34

Melania Lo Iacono, Eleonora Russo, Rita Anzalone, Elena Baiamonte, Giusi Alberti, Aldo Gerbino, Aurelio Maggio, Giampiero La Rocca, Santina Acuto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
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  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Autologous cord blood in children with cerebral palsy: a review.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melania Lo Iacono1 Campus of Hematology F. and P. Cutino, Villa Sofia-Cervello Hospital, Palermo, Italy.
Eleonora Russo2 Section of Histology and Embryology, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Rita Anzalone3 Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
Elena Baiamonte1 Campus of Hematology F. and P. Cutino, Villa Sofia-Cervello Hospital, Palermo, Italy.
Giusi Alberti3 Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
Aldo Gerbino2 Section of Histology and Embryology, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Aurelio Maggio1 Campus of Hematology F. and P. Cutino, Villa Sofia-Cervello Hospital, Palermo, Italy.
Giampiero La Rocca2 Section of Histology and Embryology, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Santina Acuto1 Campus of Hematology F. and P. Cutino, Villa Sofia-Cervello Hospital, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wharton's jelly mesenchymal stromal cells (WJ-MSCs) have been recently exploited as a feeder layer in coculture systems to expand umbilical cord blood-hematopoietic stem/progenitor cells (UCB-HSPCs). Here, we investigated the role of WJ-MSCs in supporting ex vivo UCB-HSPC expansion either when cultured in direct contact (DC) with WJ-MSCs or separated by a transwell system or in the presence of WJ-MSC-conditioned medium. We found, in short-term culture, a greater degree of expansion of UCB-CD34

Indexed as

ADP-ribosyl Cyclase 1Antigens, CD34Cell Culture TechniquesCell DifferentiationCoculture TechniquesFetal BloodHematopoietic Stem CellsHumansMesenchymal Stem CellsWharton JellyADP-ribosyl Cyclase 1Antigens, CD34extracellular matrixhematopoietic nichehematopoietic stem and progenitor cell expansionsecretomeWharton’s jelly mesenchymal stromal cells

Identifiers

PMID29562783
PMCPMC6434478

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.