Computed tomography pulmonary vascular volume ratio in children and young adults with congenital heart disease: the effect of cardiac phase.

backgroundThe effect of cardiac phase on CT pulmonary vascular volumetry is unknown.

objectiveTo evaluate the effect of cardiac phase on CT pulmonary vascular volume ratio in children and young adults with congenital heart disease. MATERIALS AND

methodsThirty-one children and young adults (median age 14 years) with congenital heart disease underwent electrocardiography-synchronized cardiothoracic CT at the end-systolic and end-diastolic phases as well as lung perfusion scintigraphy (n=20) or cardiac MRI (n=11). The author calculated right and left pulmonary vascular volumes by using threshold-based CT volumetry. Right pulmonary vascular volume percentages measured by CT obtained at the end-systolic and end-diastolic phases were compared with corresponding values measured by the reference method (lung perfusion scintigraphy or phase-contrast MRI) by using paired t-test and Bland-Altman analysis.

resultsThe right pulmonary vascular volume percentages measured by CT were significantly greater at the end-systolic phase than at the end-diastolic phase (64.0±14.1% vs. 61.9±10.7%; P<0.01). The end-systolic CT right pulmonary vascular volume percentages were not significantly different from the corresponding values measured by the reference method (64.0±14.1% vs. 65.3±13.6%; P>0.05), while the end-diastolic vascular volume percentages were significantly smaller than the corresponding values measured by the reference method (61.9±10.7% vs. 65.3±13.6%; P=0.01). Bland-Altman analysis showed a mean difference of 1.4±7.2% for the end-systolic CT, which was significantly smaller than that for the end-diastolic CT (3.4±7.0%; P<0.01).

conclusionThe CT pulmonary vascular volume ratio is significantly influenced by the cardiac phase of cardiothoracic CT. The end-systolic phase offers more accurate CT pulmonary vascular volumes than the end-diastolic phase.