Evidence map›Paper›PMID 29575178›Full record

ArticleMagnetic resonance in medicine2018

Technique development of 3D dynamic CS-EPSI for hyperpolarized

Hsin-Yu Chen, Peder E Z Larson, Jeremy W Gordon, Robert A Bok, Marcus Ferrone, Mark van Criekinge, Lucas Carvajal, Peng Cao, John M Pauly, Adam B Kerr and 7 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 51 citations in OpenAlex.

  1. Stable electron-irradiated [1-Science advances · 2025
    Article
  2. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  3. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  4. HyperpolarizedMagnetic resonance in medicine · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. A Field-Independent Method for the Rapid Generation of Hyperpolarized [1-Angewandte Chemie (International ed. in English) · 2022
    Article
  10. Article
  11. Article
  12. Specialized computational methods for denoising, BMagnetic resonance in medicine · 2021
    Article
  13. Denoising of hyperpolarizedMagnetic resonance in medicine · 2021
    Article
  14. In vivoCurrent opinion in biotechnology · 2021
    Review
  15. Achieving high-resolutionJournal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  16. Review
  17. Review
  18. HyperpolarizedNMR in biomedicine · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.ORCID 0000-0003-4183-3634
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Marcus FerroneDepartment of Clinical Pharmacy, University of California, San Francisco, California.
Mark van CriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Peng CaoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
John M PaulyElectrical Engineering, Stanford University, Stanford, California.
Adam B KerrElectrical Engineering, Stanford University, Stanford, California.
Ilwoo ParkDepartment of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Chonnam, Korea.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Sarah J NelsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Pamela N MunsterDepartment of Medicine, University of California, San Francisco, California.
Rahul AggarwalDepartment of Medicine, University of California, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
University of California, San Francisco · USStanford University · USChonnam National University Hospital · KR

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
Novel Hyperpolarized MR Markers of Advanced Prostate Cancer TherapyR01CA166655 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2012 to 2016
$3.0M
New Instrumentation and Techniques for Hyperpolarized Metabolic and Perfusion MRIR01EB013427 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2016
$2.8M
NCI NIH HHS R01 CA166655NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB013427NIBIB NIH HHS R01 EB017449
6 · The paper itself

Abstract

purposeThe purpose of this study was to develop a new 3D dynamic carbon-13 compressed sensing echoplanar spectroscopic imaging (EPSI) MR sequence and test it in phantoms, animal models, and then in prostate cancer patients to image the metabolic conversion of hyperpolarized [1-

methodsA 3D dynamic compressed sensing (CS)-EPSI sequence with spectral-spatial excitation was designed to meet the required spatial coverage, time and spatial resolution, and RF limitations of the 3T MR scanner for its clinical translation for prostate cancer patient imaging. After phantom testing, animal studies were performed in rats and transgenic mice with prostate cancers. For patient studies, a GE SPINlab polarizer (GE Healthcare, Waukesha, WI) was used to produce hyperpolarized sterile GMP [1-

resultsThrough preclinical testing, the 3D CS-EPSI sequence developed in this project was shown to provide the desired spectral, temporal, and spatial 5D HP

conclusionThe results demonstrate the feasibility to characterize prostate cancer metabolism in animals, and now patients using this new 3D dynamic HP MR technique to measure k

Indexed as

AgedAnimalsEcho-Planar ImagingHumansImaging, Three-DimensionalMaleMicePhantoms, ImagingProstateProstatic NeoplasmsPyruvic AcidRatsPyruvic Acid3D dynamic imaginghuman prostate cancerhyperpolarized C-13 pyruvate

Identifiers

PMID29575178
PMCPMC6107425
OpenAlexW2792589393

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.