Evidence map›Paper›PMID 29579102›Full record

Trial reportPloS one2018

Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in ≥ 75 years old patients: A randomized multicenter study.

Joaquin Baleztena, Miguel Ruiz-Canela, Carmen Sayon-Orea, Maria Pardo, Teresa Añorbe, Jose Ignacio Gost, Carmen Gomez, Belen Ilarregui, Maira Bes-Rastrollo

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 10 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 10 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Joaquin BaleztenaCentro Residencial Clínica Universidad de Navarra, Pamplona, Spain.ORCID 0000-0002-7202-3901
Miguel Ruiz-CanelaDepartment of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
Carmen Sayon-OreaDepartment of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.ORCID 0000-0002-4137-3263
Maria PardoGrupo Amma, Pamplona, Spain.
Teresa AñorbeGrupo Amma, Pamplona, Spain.
Jose Ignacio GostGrupo Amma, Pamplona, Spain.
Carmen GomezGrupo Amma, Pamplona, Spain.
Belen IlarreguiGrupo Amma, Pamplona, Spain.
Maira Bes-RastrolloDepartment of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
Instituto de Salud Carlos III · ESClinica Universidad de Navarra · ESComplejo Hospitalario de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A few studies have assessed the association between omega-3 polyunsaturated fatty acids (n-3 PUFA) and cognitive impairment (CI) in very old adults. The aim of this study was to evaluate the effect of a multinutrient supplementation rich in n-3 PUFA on the cognitive function in an institutionalized ≥75-year-old population without CI or with mild cognitive impairment (MCI). A multicenter placebo-controlled double-blind randomized trial was conducted between 2012 and 2013. Cognitive function was assessed at baseline and after one year using 4 neuropsychological tests. Nutritional status was assessed using Mini Nutritional Assessment (MNA). Interaction between Mini-Mental State Examination (MMSE) score and nutritional status were analyzed using linear regression models. A total of 99 participants were randomized to receive placebo or pills rich in n-3 PUFA. After 1-year follow-up, both groups decreased their MMSE score (-1.18, SD:0. 53 and -0.82, SD:0. 63, p = 0.67 for the control and the intervention group respectively). The memory subscale of the MMSE showed an improvement (+0.26, SD:0.18) in the intervention group against a worsening in the control group (-0.11, SD: 0.14; p = 0.09 for differences between groups). Patients at intervention group with normal nutritional status (MNA ≥24) showed an improvement in the MMSE (+1.03, p = 0.025 for differences between 1-y and baseline measurements) against a worsening in the group with malnutrition (MNA<24) (-0.4, p = 0.886 for differences between 1-y and baseline; p of interaction p = 0.05). Supplementation with n-3 PUFA did not show an improvement in the global cognitive function in institutionalized elderly people without CI or with MCI. They only suggest an apparent improvement in memory loss if previously they were well nourished.

Indexed as

Dietary SupplementsAgedAged, 80 and overCognitionCognitive DysfunctionDrug InteractionsFatty Acids, Omega-3FemaleHumansMaleNutritional StatusPatient ComplianceSafetyFatty Acids, Omega-3

Identifiers

PMID29579102
PMCPMC5868762
OpenAlexW2793475236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.