Evidence map›Paper›PMID 29581239›Full record

ReviewJournal of molecular endocrinology2018

Role of IGF1 and EFN-EPH signaling in skeletal metabolism.

Richard C Lindsey, Charles H Rundle, Subburaman Mohan

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of molecular endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment.Frontiers in cell and developmental biology · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Molecular signaling in bone cells: Regulation of cell differentiation and survival.Advances in protein chemistry and structural biology · 2019
    Review
  14. World leaders describe the latest in IGF research.Journal of molecular endocrinology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Richard C LindseyMusculoskeletal Disease CenterVA Loma Linda Healthcare System, Loma Linda, California, USA.
Charles H RundleMusculoskeletal Disease CenterVA Loma Linda Healthcare System, Loma Linda, California, USA.
Subburaman MohanMusculoskeletal Disease CenterVA Loma Linda Healthcare System, Loma Linda, California, USA subburaman.mohan@va.gov.
VA Loma Linda Healthcare System · USLoma Linda University · US

Funding

NIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3M
Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI DE LEON, DAISY D. · 2012 to 2016
$6.2M
Transgenic Approaches to Evaluate IGF-I Role in Peak BMDR01AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH &EDUC · PI MOHAN, SUBBURAMAN · 2003 to 2025
$4.7M
Role and Mechanism of Claudin-11 Action and Signaling in BoneR01AR070806 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2017 to 2023
$1.6M
Transgenic Approaches to Evalute IGF-1 Role in Peak BMDR56AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2008 to 2008
$258k
Ephrin Therapy for Segmental Defect Repair in BoneI01BX002519 · VA · VA LOMA LINDA HEALTHCARE SYSTEM · PI RUNDLE, CHARLES · 2015 to 2019
–
BLRD VA I01 BX002519NIAMS NIH HHS R01 AR048139NIAMS NIH HHS R01 AR070806NIAMS NIH HHS R56 AR048139NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988
6 · The paper itself

Abstract

Insulin-like growth factor 1(IGF1) and ephrin ligand (EFN)-receptor (EPH) signaling are both crucial for bone cell function and skeletal development and maintenance. IGF1 signaling is the major mediator of growth hormone-induced bone growth, but a host of different signals and factors regulate IGF1 signaling at the systemic and local levels. Disruption of the

Indexed as

AnimalsGrowth HormoneHumansInsulin-Like Growth Factor IReceptors, Eph FamilySignal TransductionSkeletonGrowth HormoneInsulin-Like Growth Factor IReceptors, Eph FamilyboneEFNEPHIGF1

Identifiers

PMID29581239
PMCPMC5966337
OpenAlexW2790512780

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.