Evidence map›Paper›PMID 29581308›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Split cGAL, an intersectional strategy using a split intein for refined spatiotemporal transgene control in

Han Wang, Jonathan Liu, Kai P Yuet, Andrew J Hill, Paul W Sternberg

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. O-acyltransferase genes involved in the production of volatile sex pheromones inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. A cGAL-UAS bipartite expression toolkit forProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Expression and Characterization of Intein-Cyclized Trimer ofInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Improved GAL4 and Tet OFF drivers formicroPublication biology · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. TheGenetics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Han WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; han.wang@caltech.edu pws@caltech.edu.ORCID 0000-0002-1933-5762
Jonathan LiuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-5761-8704
Kai P YuetDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-1381-8923
Andrew J HillDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-4621-0500
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; han.wang@caltech.edu pws@caltech.edu.ORCID 0000-0002-7699-0173
California Institute of Technology · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Bipartite gene expression system for C. elegans genetic and neural circuit analysisR21MH115454 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 2017 to 2018
$454k
Mechanisms of Sleep Regulation and Function in C. elegansK99GM126137 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, HAN · 2017 to 2018
$177k
Howard Hughes Medical InstituteNIGMS NIH HHS K99 GM126137NIGMS NIH HHS T32 GM007616NIMH NIH HHS R21 MH115454
6 · The paper itself

Abstract

Bipartite expression systems, such as the GAL4-UAS system, allow fine manipulation of gene expression and are powerful tools for interrogating gene function. Recently, we established cGAL, a GAL4-based bipartite expression system for transgene control in

Indexed as

Gene Expression RegulationInteinsTransgenesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsFungal ProteinsNeuronsPromoter Regions, GeneticProtein SplicingSaccharomycesCaenorhabditis elegans ProteinsDNA-Binding ProteinsFungal ProteinsCaenorhabditis elegansGAL4-UASinteinPKAsplit cGAL

Identifiers

PMID29581308
PMCPMC5899461
OpenAlexW2791843246

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.