ReviewPediatric cardiology2018
Mechanisms of Trabecular Formation and Specification During Cardiogenesis.
Review in Pediatric cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Cadmium impairs heart ventricular formation and disrupts polysialylated-NCAM/FGF receptor signaling in Xenopus tadpoles.Cell & bioscience · 2026Article
- Left Ventricular Hypertrabeculation: Historical Evolution, Diagnostic Pitfalls, and a Pragmatic Clinical Approach.Reviews in cardiovascular medicine · 2026Review
- 3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network.bioRxiv : the preprint server for biology · 2026Article
- 3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network.Briefings in bioinformatics · 2026Article
- PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability.National science review · 2026Article
- Broadening horizons: new links between cilia and heart development and disease.Frontiers in cardiovascular medicine · 2026Review
- Aortic Valve Annular Characteristics in Isolated Left Ventricular Non-Compaction-Detailed Analysis from the Three-Dimensional Speckle Tracking Echocardiographic MAGYAR-Path Study.Journal of clinical medicine · 2025Article
- The Congenital Malformation of the Interatrial Septum-A Review of Its Development and Embryology with Clinical Implications.Journal of developmental biology · 2025Review
- β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.Cardiovascular research · 2024Article
- Endocardial HDAC3 is required for myocardial trabeculation.Nature communications · 2024Article
- Functions of cilia in cardiac development and disease.Annals of human genetics · 2024Review
- Cardiac Development at a Single-Cell Resolution.Advances in experimental medicine and biology · 2024Article
- Myocardial Mechanics and Associated Valvular and Vascular Abnormalities in Left Ventricular Noncompaction Cardiomyopathy.Journal of clinical medicine · 2023Review
- Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development.Developmental cell · 2023Article
- Hypoplastic Left Heart Syndrome: Signaling & Molecular Perspectives, and the Road Ahead.International journal of molecular sciences · 2023Review
- Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China.Journal of cardiovascular development and disease · 2023Article
- Review
- Multimodality Imaging and Biomarker Approach to Characterize the Pathophysiology of Heart Failure in Left Ventricular Non-Compaction with Preserved Ejection Fraction.Journal of clinical medicine · 2023Article
- Advances in symptomatic therapy for left ventricular non-compaction in children.Frontiers in pediatrics · 2023Review
- Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases.Stem cell research & therapy · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Trabecular morphogenesis is a key morphologic event during cardiogenesis and contributes to the formation of a competent ventricular wall. Lack of trabeculation results in embryonic lethality. The trabecular morphogenesis is a multistep process that includes, but is not limited to, trabecular initiation, proliferation/growth, specification, and compaction. Although a number of signaling molecules have been implicated in regulating trabeculation, the cellular processes underlying mammalian trabecular formation are not fully understood. Recent works show that the myocardium displays polarity, and oriented cell division (OCD) and directional migration of the cardiomyocytes in the monolayer myocardium are required for trabecular initiation and formation. Furthermore, perpendicular OCD is an extrinsic asymmetric cell division that contributes to trabecular specification, and is a mechanism that causes the trabecular cardiomyocytes to be distinct from the cardiomyocytes in compact zone. Once the coronary vasculature system starts to function in the embryonic heart, the trabeculae will coalesce with the compact zone to thicken the heart wall, and abnormal compaction will lead to left ventricular non-compaction (LVNC) and heart failure. There are many reviews about compaction and LVNC. In this review, we will focus on the roles of myocardial polarity and OCD in trabecular initiation, formation, and specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.