ArticleCardiovascular diabetology2018
The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors.
Article in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Sleeve Gastrectomy and Gastric Bypass Decrease the Carotid Intima-Media Thickness in Obese Men: Association with Weight Loss, Cardiovascular Risk Factors, and Circulating Testosterone.Obesity surgery · 2020Trial
- Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Predictive Value of Epicardial Adipose Tissue Thickness for Plaque Vulnerability in Left Coronary Arteries: Histological Evidence from 245 Sudden Cardiac Death Cases.Diagnostics (Basel, Switzerland) · 2025Article
- Obesity-Related Serum Monocyte Chemoattractant Protein-1 (MCP-1) as a Biomarker of Plaque Instability in Patients Undergoing Carotid Endarterectomy.International journal of molecular sciences · 2025Article
- The obesity pandemic and its impact on non-communicable disease burden.Pflugers Archiv : European journal of physiology · 2025Review
- Observational
- Ultrasonography-based prediction of carotid artery atherosclerosis using multiple abdominal fat indices.Journal of ultrasonography · 2025Article
- Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence.Heliyon · 2024Review
- Sex-specific association between carotid atherosclerosis and fundus arteriosclerosis in a Chinese population: a retrospective cross-sectional study.European journal of medical research · 2023Article
- Macrophage polarization and metabolism in atherosclerosis.Cell death & disease · 2023Review
- Article
- Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis.Journal of medicine and life · 2023Article
- Body Mass Index and Late Adverse Outcomes after a Carotid Endarterectomy.International journal of environmental research and public health · 2023Article
- The Effects of Six Weeks of Fasted Aerobic Exercise on Body Shape and Blood Biochemical Index in Overweight and Obese Young Adult Males.Journal of exercise science and fitness · 2023Article
- Machine learning models for predicting the risk factor of carotid plaque in cardiovascular disease.Frontiers in cardiovascular medicine · 2023Article
- The Gupta Perioperative Risk for Myocardial Infarct or Cardiac Arrest (MICA) Calculator as an Intraoperative Neurologic Deficit Predictor in Carotid Endarterectomy.Journal of clinical medicine · 2022Article
- Cardiovascular risk factors and cervical carotid plaque features on CT angiography.The neuroradiology journal · 2022Article
- Is Obesity a Risk Factor for Carotid Atherosclerotic Disease?-Opportunistic Review.Journal of cardiovascular development and disease · 2022Review
- Genomic DNA Methylation in Diabetic Chronic Complications in Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2022Article
- Association of Carotid Plaque Morphology and Glycemic and Lipid Parameters in the Northern Manhattan Study.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the last decade, several studies have reported an unexpected and seemingly paradoxical inverse correlation between BMI and incidence of cardiovascular diseases. This so called "obesity paradox effect" has been mainly investigated through imaging methods instead of histologic evaluation, which is still the best method to study the instability of carotid plaque. Therefore, the purpose of our study was to evaluate by histology the role of obesity in destabilization of carotid plaques and the interaction with age, gender and other major cerebrovascular risk factors.
methodsA total of 390 carotid plaques from symptomatic and asymptomatic patients submitted to endarterectomy, for whom complete clinical and laboratory assessment of major cardiovascular risk factors was available, were studied by histology. Patients with a BMI ≥ 30.0 kg/m
resultsUnstable carotid plaque OR for obese patients with age < 70 years was 5.91 (95% CI 1.17-29.80), thus being the highest OR compared to that of other risk factors. Unstable carotid plaque OR decreased to 4.61 (95% CI 0.54-39.19) in males ≥ 70 years, being only 0.93 (95% CI 0.25-3.52) among women. When obesity featured among metabolic syndrome risk factors, the OR for plaque destabilization was 3.97 (95% CI 1.81-6.22), a significantly higher value compared to OR in non-obese individuals with metabolic syndrome (OR = 1.48; 95% CI 0.86-2.31). Similar results were obtained when assessing the occurrence of acute cerebrovascular symptoms.
conclusionsResults from our study appear to do not confirm any paradoxical effect of obesity on the carotid artery district. Conversely, obesity is confirmed to be an independent risk factor for carotid plaque destabilization, particularly in males aged < 70 years, significantly increasing such risk among patients with metabolic syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.