Evidence map›Paper›PMID 29599292›Full record

ArticleThe Journal of biological chemistry2018

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.

Daniel J Fazakerley, Annabel Y Minard, James R Krycer, Kristen C Thomas, Jacqueline Stöckli, Dylan J Harney, James G Burchfield, Ghassan J Maghzal, Stuart T Caldwell, Richard C Hartley and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 157 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  8. Article
  9. Review
  10. Mitochondrial medicine in obesity: a scoping review.Open medicine (Warsaw, Poland) · 2026
    Review
  11. Review
  12. Review
  13. Per- and polyfluoroalkyl substances (PFAS) toxicity and mitigation of adipogenic dysregulation in 3T3-L1 preadipocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Daniel J FazakerleyCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
Annabel Y MinardCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
James R KrycerCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
Kristen C ThomasCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
Jacqueline StöckliCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
Dylan J HarneyCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
James G BurchfieldCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia.
Ghassan J MaghzalVascular Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.
Stuart T CaldwellSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Richard C HartleySchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Roland StockerVascular Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.
Michael P MurphyMRC Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
David E JamesCharles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia; Charles Perkins Centre, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia. Electronic address: david.james@sydney.edu.au.
Cooperative Trials Group for Neuro-Oncology · AUUniversity of Glasgow · GBVictor Chang Cardiac Research Institute · AUThe University of Sydney · AUUniversity of Cambridge · GB

Funding

Medical Research Council MC_U105663142Medical Research Council MC_UU_00015/3Wellcome Trust 110158/Z/15/ZWellcome Trust 110159/Z/15/Z
6 · The paper itself

Abstract

Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they often occur in tandem, and tools that selectively increase oxidant production without impairing mitochondrial respiration have been lacking. Using the dimer/monomer status of peroxiredoxin isoforms as an indicator of compartmental hydrogen peroxide burden, we provide evidence that oxidative stress is localized to mitochondria in insulin-resistant 3T3-L1 adipocytes and adipose tissue from mice. To dissociate oxidative stress from impaired oxidative phosphorylation and study whether mitochondrial oxidative stress

Indexed as

Insulin ResistanceOxidative Phosphorylation3T3-L1 CellsAdenylate KinaseAdipocytesAnimalsElectron TransportGlucoseGlucose Transporter Type 4HerbicidesHydrogen PeroxideInsulinMaleMiceMice, Inbred C57BLMitochondriaAdenylate KinaseGlucoseGlucose Transporter Type 4HerbicidesHydrogen PeroxideInsulinParaquatPeroxiredoxinsProtein IsoformsSlc2a4 protein, mouseSuperoxidesadipocyteadipose tissuehydrogen peroxideinsulininsulin resistancemitochondriaMitochondrial dysfunctionmuscleoxidative stresssuperoxide ion

Identifiers

PMID29599292
PMCPMC5950018
OpenAlexW2794725954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.