Evidence map›Paper›PMID 29599478›Full record

Trial reportNature communications2018

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD

Christopher R Martens, Blair A Denman, Melissa R Mazzo, Michael L Armstrong, Nichole Reisdorph, Matthew B McQueen, Michel Chonchol, Douglas R Seals

6 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 345 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
345citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03642990 phase2terminatednot on this mapstarted 2019, after this paper: background citation

Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy

TypeinterventionalSponsorDonna Hammond, PhDRan2019 to 2022Enrolled5ConditionsChemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic, Platinum-resistant Recurrent Ovarian Cancer, Head and Neck Cancer Stage IVArmsNicotinamide Riboside
NCT03821623 phase2recruitingnot on this mapstarted 2019, after this paper: background citation

Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

TypeinterventionalSponsorDouglas SealsRan2019 to 2025Enrolled118ConditionsHypertension, AgingArmsNicotinamide riboside, Placebo
NCT04614714 phase2 / phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Nicotinamide Riboside and Milk Production in the NICU

TypeinterventionalSponsorUniversity of California, DavisRan2026 to 2026Enrolled40ConditionsPreterm Birth, Inadequate Milk ProductionArmsNicotinamide Riboside (NR), Placebo
NCT06521307 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery.A Randomized Controlled Pilot Study

TypeinterventionalSponsorInstituto Nacional de Cardiologia Ignacio ChavezRan2024 to 2026Enrolled100ConditionsAcute Kidney Injury, Cardiac Valve DiseaseArmsNicotinamide riboside, Placebo
NCT06587945 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomised Double-Masked Placebo-Controlled Trial of Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment

TypeinterventionalSponsorCenter for Eye Research AustraliaRan2025 to 2028Enrolled144ConditionsRetinal DetachmentArmsNicotinamide Riboside, Placebo, Vitrectomy and Gas tamponade
NCT07693543 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Randomized Crossover Trial of Nicotinamide Riboside in Chronic Kidney Disease (NR-CKD Trial)

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2028Enrolled30ConditionsChronic Kidney DiseaseArmsNicotinamide Riboside (NR), Matched Placebo (Capsules)
3 · Its place in the literature

Who cites it

345 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025
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285 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christopher R MartensDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. cmartens@udel.edu.ORCID http://orcid.org/0000-0003-0578-2948
Blair A DenmanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Melissa R MazzoDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Michael L ArmstrongDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Matthew B McQueenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
UCHSC AGING TRAINING GRANTT32AG000279 · UNIVERSITY OF COLORADO DENVER · 2001 to 2025
$2.0M
NCATS NIH HHS UL1 TR001082NIA NIH HHS T32 AG000279NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

AgedBlood PressureCaloric RestrictionDouble-Blind MethodFemaleHumansMaleMiddle AgedNADNiacinamidePyridinium CompoundsVascular StiffnessNADNiacinamidenicotinamide-beta-ribosidePyridinium Compounds

Identifiers

PMID29599478
PMCPMC5876407

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.