ArticleClinical and experimental nephrology2018
Alcohol consumption and incidence of proteinuria: a retrospective cohort study.
Article in Clinical and experimental nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Alcohol consumption and incidence of decline in glomerular filtration rate and of proteinuria: the Osaka Kenko Innovation (TOKI) study.Journal of nephrology · 2025Article
- Association between alcohol consumption and renal function in patients with diabetes mellitus and hypertension: insights from the Taiwan Biobank.BMC nephrology · 2025Observational
- Observational
- Lower body mass index potentiates the association between late-night dinner and the prevalence of proteinuria.Frontiers in endocrinology · 2025Article
- Association between alcohol consumption and chronic kidney disease: a population-based survey.Clinical and experimental nephrology · 2024Article
- The associations of cardiovascular and lifestyle factors with mortality from chronic kidney disease as the underlying cause: the JACC study.Epidemiology and health · 2024Article
- Alcohol Consumption and a Decline in Glomerular Filtration Rate: The Japan Specific Health Checkups Study.Nutrients · 2023Article
- Review
- Nutrition and quality of life in chronic kidney disease patients: a practical approach for salt restriction.Kidney research and clinical practice · 2022Article
- Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan.Nutrition journal · 2022Article
- Metabolic associated fatty liver disease is a risk factor for chronic kidney disease.Journal of diabetes investigation · 2022Article
- Preconceptional paternal alcohol consumption and the risk of child behavioral problems: a prospective cohort study.Scientific reports · 2022Article
- Lower body mass index potentiates the association between skipping breakfast and prevalence of proteinuria.Frontiers in endocrinology · 2022Article
- Change in Cardiovascular Health Metrics and Risk for Proteinuria Development: Analysis of a Nationwide Population-Based Database.American journal of nephrology · 2022Observational
- Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease.Scientific reports · 2021Article
- Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study.Nutrients · 2020Article
- Frequency of alcohol drinking modifies the association between salt intake and albuminuria: a 1-year observational study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Observational
- Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study.Clinical and experimental nephrology · 2020Article
- Alcohol Consumption Can be a "Double-Edged Sword" for Chronic Kidney Disease Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies report conflicting results of a dose-dependent association between alcohol consumption and incidence of chronic kidney disease. Only a few studies have assessed the clinical impact of > 45-65 g/day of critically high alcohol consumption.
methodsThis retrospective cohort study included 88,647 males and 88,925 females with dipstick urinary protein ≤ ± and estimated glomerular filtration rate ≥ 60 mL/min/1.73 m
resultsDuring median 1.8 years (interquartile range 1.0-2.1) of the observational period, 5416 (6.1%) males and 3262 (3.7%) females developed proteinuria defined as dipstick urinary protein ≥ 1 +. In males, a U-shape association between alcohol consumption and proteinuria was observed in a multivariable-adjusted Poisson regression model [incidence rate ratio (95% confidence interval) of rare, occasional, and daily drinkers with ≤ 19, 20-39, 40-59, and ≥ 60 g/day: 1.00 (reference), 0.86 (0.79-0.94), 0.70 (0.64-0.78), 0.82 (0.75-0.90), 1.00 (0.90-1.11), and 1.00 (0.85-1.17), respectively], whereas a J-shape association was observed in females [1.00 (reference), 0.81 (0.75-0.87), 0.74 (0.64-0.85), 0.93 (0.78-1.11), 1.09 (0.83-1.44), and 1.45 (1.02-2.08), respectively]. Similar associations with dipstick urinary protein ≥ 2 + were shown in males and females.
conclusionsModerate alcohol consumption was associated with lower risk of proteinuria in both males and females. Females with ≥ 60 g/day of high alcohol consumption were at higher risk of proteinuria, whereas males were not. Females were more vulnerable to high alcohol consumption, than males.
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Registered trials
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