Evidence map›Paper›PMID 29602245›Full record

ArticleImmunity, inflammation and disease2018

Reactive glia promote development of CD103

Sujata Prasad, Shuxian Hu, Wen S Sheng, Priyanka Chauhan, James R Lokensgard

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Evolving role of CD8Frontiers in immunology · 2026
    Review
  3. bTInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Tissue-resident immune cells in the pathogenesis of multiple sclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  7. Keeping T cell memories in mind.Trends in immunology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Functionally Competent, PD-1Frontiers in immunology · 2020
    Article
  13. Review
  14. Glial Cell Expression of PD-L1.International journal of molecular sciences · 2019
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sujata PrasadNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minnesota, USA.
Shuxian HuNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minnesota, USA.
Wen S ShengNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minnesota, USA.
Priyanka ChauhanNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minnesota, USA.
James R LokensgardNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minnesota, USA.ORCID 0000-0002-1976-2035
University of Minnesota · US

Funding

Role of B-cells and CNS antibodies in modulating chronic microglial activationR01NS038836 · NINDS · UNIVERSITY OF MINNESOTA · PI LOKENSGARD, JAMES R · 2000 to 2022
$7.3M
T lymphocyte-induced glial activation during CNS immune reconstitution diseaseR01MH066703 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOKENSGARD, JAMES R · 2003 to 2023
$6.9M
NIMH NIH HHS R01 MH066703NINDS NIH HHS R01 NS038836
6 · The paper itself

Abstract

introductionPrevious work from our laboratory has demonstrated in vivo persistence of CD103

methodsWe performed flow cytometric analysis of cells from co-cultures of mixed glia and CD8

resultsIn this study, we show that interactions between reactive glia and anti-CD3 Ab-stimulated CD8

conclusionsTaken together, these results demonstrate a role for activated glia in promoting development of bT

Indexed as

Immunologic MemoryAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteB7-H1 AntigenBrainCD69 AntigensCD8-Positive T-LymphocytesCells, CulturedCentral Nervous System Viral DiseasesCoculture TechniquesDisease Models, AnimalFemaleFlow CytometryHerpesviridae InfectionsHumansalpha E integrinsAntigens, CDAntigens, Differentiation, T-LymphocyteB7-H1 AntigenCd274 protein, mouseCD69 AntigensIntegrin alpha ChainsLectins, C-TypePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorbTRMCD103central nervous systemglial cellsPD-L1

Identifiers

PMID29602245
PMCPMC5946148
OpenAlexW2795270277

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.