Surrogate endpoints in global health research: still searching for killer apps and silver bullets?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it.

1. Implementation strategies to increase the uptake and impact of molecular WHO-recommended rapid diagnostic tests: evidence from a mixed-methods systematic review.BMJ global health · 2025
   Pooled it
2. Rapid molecular tests for tuberculosis and tuberculosis drug resistance: a qualitative evidence synthesis of recipient and provider views.The Cochrane database of systematic reviews · 2022
   Pooled it
3. Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis.The Cochrane database of systematic reviews · 2021
   Pooled it
4. Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis.The Cochrane database of systematic reviews · 2021
   Pooled it
5. Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults.The Cochrane database of systematic reviews · 2019
   Pooled it
6. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis.The New England journal of medicine · 2021
   Trial
7. AI-Enhanced Point-of-Care Diagnostics for Infectious Diseases in Resource-Limited Settings: A Scoping Review.Tropical medicine & international health : TM & IH · 2026
   Article
8. Improving the efficiency of drug resistant tuberculosis treatment trials: a time-to-event alternative marker for bacteriological response and adaptive minimization for randomization.BMC medical research methodology · 2025
   Article
9. Reimagining Innovation in Health Equity: Making a Case for a Community embedded Participatory Learning Site for Adivasi Health Research.Journal of community systems for health · 2025
   Article
10. Multidrug-resistant tuberculosis.Nature reviews. Disease primers · 2024
    Review
11. Power Relations in Optimisation of Therapies and Equity in Access to Antibiotics (PROTEA) Study: investigating the intersection of socio-economic and cultural drivers on antimicrobial resistance (AMR) and its influence on healthcare access and health-providing behaviours in India and South Africa.Wellcome open research · 2024
    Article
12. Use of the urine Determine LAM test in the context of tuberculosis diagnosis among inpatients with HIV in Ghana: a mixed methods study.Frontiers in public health · 2023
    Article
13. Single-issue advocacy in global health: Possibilities and perils.PLOS global public health · 2023
    Article
14. The potential of digital molecular diagnostics for infectious diseases in sub-Saharan Africa.PLOS digital health · 2022
    Review
15. Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?EBioMedicine · 2022
    Review
16. Funders: The missing link in equitable global health research?PLOS global public health · 2022
    Review
17. Saving babies' lives (SBL) - a programme to reduce neonatal mortality in rural Cambodia: study protocol for a stepped-wedge cluster-randomised trial.BMC pediatrics · 2021
    Article
18. Progress toward Developing Sensitive Non-Sputum-Based Tuberculosis Diagnostic Tests: the Promise of Urine Cell-Free DNA.Journal of clinical microbiology · 2021
    Article
19. Advances in Molecular Diagnosis of Tuberculosis.Journal of clinical microbiology · 2020
    Review
20. Closing gaps in the tuberculosis care cascade: an action-oriented research agenda.Journal of clinical tuberculosis and other mycobacterial diseases · 2020
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as