ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways.Molecules (Basel, Switzerland) · 2022Review
- Latest research progress on anticancer effect of baicalin and its aglycone baicalein.Archives of pharmacal research · 2022Review
- The Use of Chinese Skullcap (Animals : an open access journal from MDPI · 2021Review
- Protective Effects of Baicalin on Peritoneal Tight Junctions in Piglets Challenged withMolecules (Basel, Switzerland) · 2021Article
- Exploring the Potential Molecular Mechanism ofFrontiers in pharmacology · 2021Article
- Baicalin Protects Vascular Tight Junctions in Piglets DuringFrontiers in veterinary science · 2021Article
- Surfactin fromJournal of Cancer · 2020Article
- Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity ofChinese medicine · 2020Review
- Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway.Drug design, development and therapy · 2020Article
- Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway.Oncology letters · 2019Article
- Comparative Investigation for Rotten Xylem (kuqin) and Strip Types (tiaoqin) ofMolecules (Basel, Switzerland) · 2019Article
- Anti-Proliferation and Pro-Apoptotic Effects of Diosmetin via Modulating Cell Cycle Arrest and Mitochondria-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cells.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase.Bioscience reports · 2019Article
- Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes.Frontiers in pharmacology · 2019Review
- Downregulation of Krüppel‑like factor 1 inhibits the metastasis and invasion of cervical cancer cells.Molecular medicine reports · 2018Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Like other human cancers, the malignancy of cervical cancer is also characterized by abilities of proliferation, migration, and invasion. Protein kinase C-zeta (PKCζ) has been highly correlated with several human cancers. Baicalin was proven to regulate PKC. This study aimed to investigate the anti-cancer effect and involved molecular mechanisms of baicalin on human cervical cancer. MATERIAL AND METHODS Baicalin at various concentrations was used to treat 2 human cervical cancer cell lines HeLa and SiHa. The proliferation was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenylterazolium bromide (MTT) assay. The apoptosis was detected by terminal transferase UTP nick end labeling (TUNEL) assay. Wound healing assay and Transwell assay were used to evaluate the migration and invasion respectively. Western blotting was performed to assess the protein expression levels. RESULTS Baicalin administration significantly reduced the viability by facilitating the apoptosis in HeLa and SiHa cells. Baicalin treatment also significantly reduced the wound closure and cell amount invaded as measured by Transwell assay. The expression levels of PKCζ, survivin, matrix metalloproteinase (MMP)2, MMP9 as well as the phosphorylation of signal transducer and activator of transcription (STAT) 3 were reduced in baicalin administrated cervical cancer cells. CONCLUSIONS Baicalin exerted anti-cancer effects on human cervical cancer cells by targeting STAT3 regulated signaling pathways.
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