Evidence map›Paper›PMID 29614993›Full record

Trial reportBMC cancer2018

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial.

Jacqueline K Dawson, Tanya B Dorff, E Todd Schroeder, Christianne J Lane, Mitchell E Gross, Christina M Dieli-Conwright

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 11 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01909440 nacompletednot on this map

Exercise and Protein Supplementation for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2013 to 2018Enrolled43ConditionsProstate CancerArmsexercise intervention, nutritional supplementation, quality-of-life assessment, questionnaire administration, pharmacological study
NCT06828003 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Remotely-Delivered Resistance Training Program for Cognitive Function in Men Living With and Beyond Prostate Cancer: A Feasibility Study

TypeinterventionalSponsorUniversity of TorontoRan2025 to 2026Enrolled30ConditionsProstate Cancer, Resistance TrainingArmsResistance Training
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 11 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Inclusivity in prostate cancer and exercise research: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Does Androgen Deprivation for Prostate Cancer Affect Normal Adaptation to Resistance Exercise?International journal of environmental research and public health · 2022
    Pooled it
  6. Pooled it
  7. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Pooled it
  11. Pooled it
  12. Trial
  13. Effect of exercise on body composition among women with ovarian cancer.Journal of cancer survivorship : research and practice · 2023
    Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Review
  19. Subcutaneous adipose tissue outperforms muscle strength as an indicator of survival and quality of life in patients with cancer: a multicenter cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jacqueline K DawsonDivison of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP-155, Los Angeles, CA, 90033, USA. kiwata@alumni.usc.edu.
Tanya B DorffNorris Comprehensive Cancer Center, Keck School of Medicine (KSOM), Los Angeles, CA, USA.
E Todd SchroederDivison of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP-155, Los Angeles, CA, 90033, USA.
Christianne J LaneDepartment of Preventive Medicine, KSOM, Los Angeles, CA, USA.
Mitchell E GrossEllison Institute for Transformative Medicine, KSOM, Los Angeles, CA, USA.
Christina M Dieli-ConwrightDivison of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP-155, Los Angeles, CA, 90033, USA.
University of Southern California · USLarry Ellison Foundation · USUSC Norris Comprehensive Cancer Center · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$9.1M
NCATS NIH HHS UL1 TR001855NCI NIH HHS K07 CA160718NCI NIH HHS K07CA160718Southern California Clinical and Translational Science Institute UL1TR001855
6 · The paper itself

Abstract

backgroundProstate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS). Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS. This pilot trial investigated 12 weeks of resistance training on body composition and MetS changes in prostate cancer patients on ADT. An exploratory aim examined if a combined approach of training and protein supplementation would elicit greater changes in body composition.

methodsProstate cancer patients on ADT were randomized to resistance training and protein supplementation (TRAINPRO), resistance training (TRAIN), protein supplementation (PRO), or control stretching (STRETCH). Exercise groups (EXE = TRAINPRO, TRAIN) performed supervised exercise 3 days per week for 12 weeks, while non-exercise groups (NoEXE = PRO, STRETCH) performed a home-based stretching program. TRAINPRO and PRO received 50 g⋅day

resultsA total of 37 participants were randomized; 32 participated in the intervention (EXE n = 13; NoEXE n = 19). At baseline, 43.8% of participants were sarcopenic and 40.6% met the criteria for MetS. Post-intervention, EXE significantly improved lean mass (d = 0.9), sarcopenia prevalence (d = 0.8), body fat % (d = 1.1), strength (d = 0.8-3.0), and prostate cancer-specific quality of life (d = 0.9) compared to NoEXE (p < 0.05). No significant differences were observed between groups for physical function or MetS-related variables except waist circumference (d = 0.8).

conclusionsA 12-week resistance training intervention effectively improved sarcopenia, body fat %, strength and quality of life in hypogonadal prostate cancer patients, but did not change MetS or physical function. PRO did not offer additional benefit in improving body composition.

trial registrationClinicalTrials.gov: NCT01909440 . Registered 24 July 2013.

Indexed as

Body CompositionResistance TrainingAndrogen AntagonistsAntineoplastic Agents, HormonalBiomarkersDietHome Care ServicesHumansMaleMedication AdherenceMetabolic SyndromeMuscle StrengthPhysical FitnessPhysical Functional PerformancePilot ProjectsProstatic NeoplasmsAndrogen AntagonistsAntineoplastic Agents, HormonalBiomarkersBody fatMetabolic syndromeMuscle massProstate cancerProtein supplementationSarcopeniaStrength trainingSurvivorship

Identifiers

PMID29614993
PMCPMC5883585
OpenAlexW2807622313

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.