ArticleThe New England journal of medicine2018
Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes.
Article in The New England journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 177 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Young Adults With Early-onset Obesity Treated With Semaglutide -The RESETTLE Study
Time Restricted Eating in Childhood Obesity: An Open-Label, Blinded-Endpoint, Parallel-Controlled, Randomized Clinical Trial
Who cites it
177 citing papers in PubMed, 7 syntheses or guidelines pooled it, 375 citations in OpenAlex.
- Surgery for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Effects of rapid growth on fasting insulin and insulin resistance: a system review and meta-analysis.European journal of clinical nutrition · 2021Pooled it
- Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.PLoS genetics · 2020Pooled it
- Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.Cardiovascular diabetology · 2020Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- Can antenatal diet and lifestyle interventions influence childhood obesity? A systematic review.Maternal & child nutrition · 2018Pooled it
- Efficacy of a Digital Peer Support Program on Weight Management and Mental Health in University Students With Preobesity: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Feasibility and efficacy of adding high-intensity interval training to a multidisciplinary lifestyle intervention in children with obesity-a randomized controlled trial.International journal of obesity (2005) · 2025Trial
- Effects of a Family-Based Lifestyle Intervention Plus Supervised Exercise Training on Abdominal Fat Depots in Children With Overweight or Obesity: A Secondary Analysis of a Nonrandomized Clinical Trial.JAMA network open · 2022Trial
- Trial
- Mindfulness-based intervention in adolescents at risk for excess weight gain: 1.5-year follow-up of pilot randomized controlled trial.Eating behaviors · 2021Trial
- Mindfulness-based group intervention in adolescents at-risk for excess weight gain: A randomized controlled pilot study.Appetite · 2019Trial
- A body mass index over 22 kg/m2 at college age is a risk factor for future diabetes in Japanese men.PloS one · 2019Trial
- Design, synthesis, and stability evaluation of semaglutide-derived lactam-stapled peptide scaffolds for GLP-1R targeting.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Obesity in Late Adolescence and Healthcare Costs in Young to Mid-Adulthood.Diabetes, obesity & metabolism · 2026Article
- Impact of an Intensive Lifestyle Camp on Anthropometry and Quality of Life in Vulnerable Children: A 3-Year Follow-Up of a Nonrandomized Clinical Trial.Obesity facts · 2026Article
- Municipality-Based Lifestyle Intervention of Childhood Overweight and Obesity: 4-Years Follow-Up on BMI Trajectories.Clinical obesity · 2026Article
- Predictive epigenetic biomarkers of successful weight-loss intervention in pre-pubertal children with obesity.Clinical epigenetics · 2026Article
- Childhood body mass index trajectories and risk of overweight and obesity in young adulthood: a population-based prospective cohort study.European journal of pediatrics · 2026Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood overweight is associated with an increased risk of type 2 diabetes in adulthood. We investigated whether remission of overweight before early adulthood reduces this risk.
methodsWe conducted a study involving 62,565 Danish men whose weights and heights had been measured at 7 and 13 years of age and in early adulthood (17 to 26 years of age). Overweight was defined in accordance with Centers for Disease Control and Prevention criteria. Data on type 2 diabetes status (at age ≥30 years, 6710 persons) were obtained from a national health registry.
resultsOverweight at 7 years of age (3373 of 62,565 men; 5.4%), 13 years of age (3418 of 62,565; 5.5%), or early adulthood (5108 of 62,565; 8.2%) was positively associated with the risk of type 2 diabetes; associations were stronger at older ages at overweight and at younger ages at diagnosis of type 2 diabetes. Men who had had remission of overweight before the age of 13 years had a risk of having type 2 diabetes diagnosed at 30 to 60 years of age that was similar to that among men who had never been overweight (hazard ratio, 0.96; 95% confidence interval [CI], 0.75 to 1.21). As compared with men who had never been overweight, men who had been overweight at 7 and 13 years of age but not during early adulthood had a higher risk of type 2 diabetes (hazard ratio, 1.47; 95% CI, 1.10 to 1.98), but their risk was lower than that among men with persistent overweight (hazard ratio [persistently overweight vs. never overweight], 4.14; 95% CI, 3.57 to 4.79). An increase in body-mass index between 7 years of age and early adulthood was associated with an increased risk of type 2 diabetes, even among men whose weight had been normal at 7 years of age.
conclusionsChildhood overweight at 7 years of age was associated with increased risks of adult type 2 diabetes only if it continued until puberty or later ages. (Funded by the European Union.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.