Evidence map›Paper›PMID 29623692›Full record

ArticleThe Journal of physiology2018

Daily muscle stretching enhances blood flow, endothelial function, capillarity, vascular volume and connectivity in aged skeletal muscle.

Kazuki Hotta, Bradley J Behnke, Bahram Arjmandi, Payal Ghosh, Bei Chen, Rachael Brooks, Joshua J Maraj, Marcus L Elam, Patrick Maher, Daniel Kurien and 5 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04471792 (Creatine Monohydrate Use and Muscle Stretching in Peripheral Artery Disease), which is not on this map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04471792 phase2completednot on this mapstarted 2020, after this paper: background citation

Creatine Monohydrate Use and Muscle Stretching in Peripheral Artery Disease

TypeinterventionalSponsorFlorida State UniversityRan2020 to 2022Enrolled13ConditionsPeripheral Arterial DiseaseArmsCreatine monohydrate, Cellulose
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  17. Effects of chronic volume deprivation on the ventricle.Interdisciplinary cardiovascular and thoracic surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Kazuki HottaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.ORCID 0000-0002-8639-2521
Bradley J BehnkeDepartment of Kinesiology, Kansas State University College of Human Ecology, Manhattan, KS, USA.
Bahram ArjmandiDepartment of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL, USA.
Payal GhoshDepartment of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL, USA.
Bei ChenDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Rachael BrooksDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Joshua J MarajDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Marcus L ElamDepartment of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL, USA.
Patrick MaherDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Daniel KurienDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Alexandra ChurchillDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Jaime L SepulvedaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Max B KabolowskyDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Demetra D ChristouDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA.
Judy M Muller-DelpDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.ORCID 0000-0001-5322-0611
Florida State University · USUniversity of Florida · USKansas State University · US

Funding

Ankle dorsiflexion splinting enhances endothelial function of aged leg musclesR21AG044858 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTOU, DEMETRA, DELP, JUDY M · 2013 to 2014
$401k
NIA NIH HHS R21 AG044858
6 · The paper itself

Abstract

key pointsIn aged rats, daily muscle stretching increases blood flow to skeletal muscle during exercise. Daily muscle stretching enhanced endothelium-dependent vasodilatation of skeletal muscle resistance arterioles of aged rats. Angiogenic markers and capillarity increased in response to daily stretching in muscles of aged rats. Muscle stretching performed with a splint could provide a feasible means of improving muscle blood flow and function in elderly patients who cannot perform regular aerobic exercise. ABSTRACT: Mechanical stretch stimuli alter the morphology and function of cultured endothelial cells; however, little is known about the effects of daily muscle stretching on adaptations of endothelial function and muscle blood flow. The present study aimed to determine the effects of daily muscle stretching on endothelium-dependent vasodilatation and muscle blood flow in aged rats. The lower hindlimb muscles of aged Fischer rats were passively stretched by placing an ankle dorsiflexion splint for 30 min day

Indexed as

AgingBlood VolumeHemodynamicsPhysical Conditioning, AnimalAnimalsCapillary ActionEndothelium, VascularMaleMuscle, SkeletalMuscle Stretching ExercisesRatsRats, Inbred F344endotheliumexercise hyperemiahypoxia inducible factor-1 alphanitric oxide synthase

Identifiers

PMID29623692
PMCPMC5978284
OpenAlexW2803467576

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.