Evidence map›Paper›PMID 29623912›Full record

ReviewNeural regeneration research2018

Cerebral ischemia and neuroregeneration.

Reggie H C Lee, Michelle H H Lee, Celeste Y C Wu, Alexandre Couto E Silva, Harlee E Possoit, Tsung-Han Hsieh, Alireza Minagar, Hung Wen Lin

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Neural regeneration research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 203 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. GlyT1 (SLC6A9) inhibition in neurological and psychiatric disorders.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Dichloromethane Extract fromAntioxidants (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Reggie H C LeeDepartment of Neurology, Louisiana State University Health Science Center; Center for Brain Health, Louisiana State University Health Science Center, Shreveport, LA, USA.
Michelle H H LeeInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan, China.
Celeste Y C WuDepartment of Neurology, Louisiana State University Health Science Center; Center for Brain Health, Louisiana State University Health Science Center, Shreveport, LA, USA.
Alexandre Couto E SilvaDepartment of Cellular Biology and Anatomy, Louisiana State University Health Science Center, Shreveport, LA, USA.
Harlee E PossoitDepartment of Neurology, Louisiana State University Health Science Center; Center for Brain Health, Louisiana State University Health Science Center, Shreveport, LA, USA.
Tsung-Han HsiehDepartment of Neurology, Louisiana State University Health Science Center; Center for Brain Health, Louisiana State University Health Science Center, Shreveport, LA, USA.
Alireza MinagarDepartment of Neurology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Hung Wen LinDepartment of Neurology, Louisiana State University Health Science Center; Center for Brain Health, Louisiana State University Health Science Center; Department of Cellular Biology and Anatomy, Louisiana State University Health Science Center, Shreveport, LA, USA; Cardiovascular and Metabolomics Research Center, Hualien Tzu Chi Hospital, Hualien, Taiwan, China.
Louisiana State University Health Sciences Center Shreveport · USNational Health Research Institutes · TW

Funding

Vascular Regulatory Mechanisms of Palmitic Acid Methyl EsterR01NS096225 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI LIN, HUNG WEN (KEVIN) · 2017 to 2021
$1.6M
American Heart Association-American Stroke Association 17GRNT33660336NINDS NIH HHS R01 NS096225
6 · The paper itself

Abstract

Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies against stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

Indexed as

cerebral ischemiafatty acidsmelatoninneuromodulation therapypifithrin-αprotein kinase Cresveratrolstem cellsympathetic nervous systemtraditional Chinese therapies

Identifiers

PMID29623912
PMCPMC5900490
OpenAlexW2795560018

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.