Evidence map›Paper›PMID 29625592›Full record

ArticleBiology of sex differences2018

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.

James L J Coleman, Margaret A Mouat, Jianxin Wu, Nikola Jancovski, Jaspreet K Bassi, Andrea Y Chan, David T Humphreys, Nadine Mrad, Ze-Yan Yu, Tony Ngo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  2. Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  3. Article
  4. Impaired Aversive Memory Formation in GPR37L1KO Mice.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Mouse Mutants ofInternational journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

James L J ColemanMolecular Pharmacology Laboratory, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia.
Margaret A MouatMolecular Pharmacology Laboratory, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia.
Jianxin WuCardiac Biology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Nikola JancovskiDepartment of Physiology, University of Melbourne, Melbourne, Australia.
Jaspreet K BassiDepartment of Physiology, University of Melbourne, Melbourne, Australia.
Andrea Y ChanCardiac Biology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
David T HumphreysSt Vincent's Clinical School, University of New South Wales, Sydney, Australia.
Nadine MradMolecular Pharmacology Laboratory, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia.
Ze-Yan YuSt Vincent's Clinical School, University of New South Wales, Sydney, Australia.
Tony NgoMolecular Pharmacology Laboratory, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia.
Siiri IismaaSt Vincent's Clinical School, University of New South Wales, Sydney, Australia.
Cristobal G Dos RemediosCardiac Research Laboratory, University of Sydney, Camperdown, Australia.
Michael P FeneleySt Vincent's Clinical School, University of New South Wales, Sydney, Australia.
Andrew M AllenDepartment of Physiology, University of Melbourne, Melbourne, Australia.
Robert M GrahamSt Vincent's Clinical School, University of New South Wales, Sydney, Australia.
Nicola J SmithMolecular Pharmacology Laboratory, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia. n.smith@victorchang.edu.au.
Victor Chang Cardiac Research Institute · AUUNSW Sydney · AUUniversity of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and detectable as mRNA in the heart and kidney. GPR37L1 ablation was reported to cause hypertension and left ventricular hypertrophy, and thus, we sought to further define the role of GPR37L1 in blood pressure homeostasis.

methodsWe investigated the cardiovascular effects of GPR37L1 using wild-type (GPR37L1

resultsGPR37L1 protein was abundant in the brain but not detectable in the heart and kidney. We measured blood pressure in GPR37L1

conclusionsDespite its absence in the heart and kidney, GPR37L1 regulates baseline blood pressure in female mice and is crucial for cardiovascular compensatory responses in males. The expression of GPR37L1 in the brain, yet absence from peripheral cardiovascular tissues, suggests this orphan receptor is a hitherto unknown contributor to central cardiovascular control.

Indexed as

Blood PressureAnimalsBrainFemaleFibrosisKidneyMaleMice, Inbred C57BLMice, KnockoutMyocardiumReceptors, G-Protein-CoupledSex CharacteristicsGpr37l1 protein, mouseReceptors, G-Protein-CoupledCentral nervous systemG protein-coupled receptorsHeart failureHypertensionLeft ventricular hypertrophyMouse model of hypertensionOrphan

Identifiers

PMID29625592
PMCPMC5889568
OpenAlexW2800868685

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.