Evidence map›Paper›PMID 29632177›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2018

β-Amyloid accumulation in the human brain after one night of sleep deprivation.

Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E Wiers, Sukru B Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman and 7 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05568381 (Sleep Disturbance in MCI), which is not on this map. Cited by 477 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
477citing papers in PubMed, 3 pooled it
41.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05568381 nacompletednot on this mapstarted 2023, after this paper: background citation

Sleep Disturbance in MCI: A Pilot Study of a Cognitive Behavioural Therapy Digital Intervention (SUCCEED)

TypeinterventionalSponsorUniversity of SydneyRan2023 to 2023Enrolled40ConditionsCognitive Dysfunction, Insomnia, Mild Cognitive Impairment, Cognitive DisorderArmsdigital CBT-I, Online Sleep Health Education package
3 · Its place in the literature

Who cites it

477 citing papers in PubMed, 3 syntheses or guidelines pooled it, 836 citations in OpenAlex.

  1. Pooled it
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  5. Testing effects of paced breathing on plasma Aβ and brain perivascular spaces.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2026
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417 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Ehsan Shokri-KojoriLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892; ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov.ORCID 0000-0001-6846-3173
Gene-Jack WangLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892; ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov.
Corinde E WiersLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Sukru B DemiralLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Min GuoLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Sung Won KimLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Elsa LindgrenLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Veronica RamirezLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Amna ZehraLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Clara FreemanLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Gregg MillerLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Peter ManzaLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Tansha SrivastavaLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Susan De SantiPiramal Pharma Inc., Boston, MA 02108.
Dardo TomasiLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Helene BenvenisteDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06510.
Nora D VolkowLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892; ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov.
National Institutes of Health · USPiramal (United States) · USYale University · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8M
NINDS NIH HHS R01 NS100366
6 · The paper itself

Abstract

The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. Here we used PET and

Indexed as

AdultAgedAlzheimer DiseaseAmyloid beta-PeptidesApolipoproteins EFemaleGenotypeHippocampusHumansMaleMiddle AgedRisk FactorsSleep DeprivationThalamusAmyloid beta-PeptidesApoE protein, humanApolipoproteins EAlzheimer’s diseasebeta amyloidglymphatic systemhippocampussleep

Identifiers

PMID29632177
PMCPMC5924922
OpenAlexW2797347068

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.