Evidence map›Paper›PMID 29632235›Full record

ArticleBlood advances2018

Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor.

Gauthami Jalagadugula, Lawrence E Goldfinger, Guangfen Mao, Michele P Lambert, A Koneti Rao

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Transcription factor RUNX1 regulates coagulation factor XIII-A (Research and practice in thrombosis and haemostasis · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gauthami JalagadugulaSol Sherry Thrombosis Research Center and.
Lawrence E GoldfingerSol Sherry Thrombosis Research Center and.
Guangfen MaoSol Sherry Thrombosis Research Center and.
Michele P LambertDepartment of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and.
A Koneti RaoSol Sherry Thrombosis Research Center and.ORCID 0000-0002-3078-7778
Thrombosis Research Institute · GBChildren's Hospital of Philadelphia · US

Funding

Human Platelet Defects in Transcription Factor RUNX1 HaplodeficiencyR01HL109568 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2013 to 2022
$3.4M
Novel small G protein pathway regulators of GPVI signaling in plateletsR01HL137207 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GOLDFINGER, LAWRENCE E, KUNAPULI, SATYA P. · 2017 to 2020
$2.5M
Runx1 Haplodeficiency, Endocytosis and Vesicle transportR01HL137376 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL109568NHLBI NIH HHS R01 HL137207NHLBI NIH HHS R01 HL137376
6 · The paper itself

Abstract

Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression profiling of a patient with a heterozygous

Indexed as

Blood PlateletsCase-Control StudiesCells, CulturedChildChild, PreschoolCore Binding Factor Alpha 2 SubunitEndoplasmic ReticulumFemaleGolgi ApparatusHumansLeukemia, Erythroblastic, AcuteMaleMegakaryocytesPromoter Regions, GeneticProtein BindingProtein TransportCore Binding Factor Alpha 2 SubunitRab1B protein, humanrab1 GTP-Binding ProteinsRUNX1 protein, humanvon Willebrand Factor

Identifiers

PMID29632235
PMCPMC5894258
OpenAlexW2797913249

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.