Evidence map›Paper›PMID 29634343›Full record

ArticleAntioxidants & redox signaling2018

Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.

Christopher Hine, Yan Zhu, Anthony N Hollenberg, James R Mitchell

Abstract read
In one paragraph

Article in Antioxidants & redox signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

  1. A Paradigm Shift of HCurrent issues in molecular biology · 2026
    Review
  2. Gut microbe-derivedProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Sirt6 prevents the age-related decline of HProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  5. Sulfide regulation and catabolism in health and disease.Signal transduction and targeted therapy · 2025
    Review
  6. Article
  7. Review
  8. Hydrogen sulfide and its role in female reproduction.Frontiers in veterinary science · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Intracellular HCell chemical biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Christopher Hine1 Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute , Cleveland, Ohio.
Yan Zhu2 Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts.
Anthony N Hollenberg2 Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts.
James R Mitchell3 Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
Beth Israel Deaconess Medical Center · USCleveland Clinic Lerner College of Medicine · USHarvard University · US

Funding

Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Protection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6M
Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747k
Dietary restriction promotes vascular health through hydrogen sulfide-mediated angiogenesisR56AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2017 to 2017
$398k
NIA NIH HHS R00 AG050777NIA NIH HHS R01 AG036712NIA NIH HHS R56 AG036712NIDDK NIH HHS R01 DK090629
6 · The paper itself

Abstract

significanceHydrogen sulfide (H CRITICAL ISSUES: Here, we discuss the role of dietary SAAs and growth hormone (GH)/thyroid hormone (TH) signaling in regulation of endogenous H FUTURE DIRECTIONS: The relative contribution of increased H

Indexed as

DietLongevityAnimalsEndocrine GlandsHumansHydrogen SulfideHydrogen Sulfideagingcystathionine γ-lyasedietary restrictiongrowth hormonehydrogen sulfidethyroid hormone

Identifiers

PMID29634343
PMCPMC5930795
OpenAlexW2797072101

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.