ArticleBalkan medical journal2018
L-Cysteine Partially Protects Against Acrylamide-Induced Testicular Toxicity.
Article in Balkan medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Morphological analysis and cytotoxicity of acrylamide on SPC212 human mesothelioma cells: Do low doses induce proliferation, while high doses cause toxicity?Journal of cellular and molecular medicine · 2024Article
- Impacts of Acrylamide on testis and spermatozoa.Molecular biology reports · 2024Review
- Effect of vitamin C on histomorphometric changes of testis, epididymis, prostate, and seminal vesicle induced by acrylamide in rat.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Free-L-Cysteine improves corticosterone-induced behavioral deficits, oxidative stress and neurotransmission in rats.Metabolic brain disease · 2023Article
- Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.Environmental science and pollution research international · 2021Article
- The Protective Agents Used against Acrylamide Toxicity: AnCell journal · 2021Review
- Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats.Journal of toxicologic pathology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcrylamide is a widespread substance having many areas of utilization. Besides, it also forms a part of high-temperature processed starchy foods. To date, numerous in vivo and in vitro studies have documented that acrylamide has toxic effects on various organ systems.
aimsTo determine the potential protective effect of L-cysteine on acrylamide-induced testicular toxicity. STUDY
designAnimal experimentation.
methodsWe randomly divided 28 rats into four groups as control (0.9% saline), L-cysteine (150 mg/kg), acrylamide (40 mg/kg) and acrylamide + L-cysteine. After a 10-day intraperitoneal injection period, we euthanized the animals, recorded their body and testis weights, collected blood samples for serum testosterone measurement, and excised testes for histopathological and morphometric evaluation. Besides, immunohistochemical scoring of proliferating cell nuclear antigen and bax proteins was performed.
resultsAcrylamide reduced body (p<0.01) and testis weights (p<0.05), seminiferous tubule diameter (p<0.001) and proliferating cell nuclear antigen expression (p<0.05), while it increased bax protein expression (p<0.01) and the percentage of seminiferous tubules that contain multinucleated giant cells (p<0.001), but did not significantly change serum testosterone levels when compared to control. L-cysteine administered with acrylamide decreased multinucleated giant cell number (p<0.001) and reversed the reduced proliferating cell nuclear antigen positivity (p<0.001), but did not restore other parameters compared with the acrylamide alone-treated group.
conclusionTaking into account the dose and duration employed, the present study concluded that L-cysteine partially protects testis against acrylamide-induced toxic effects.
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Registered trials
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