Evidence map›Paper›PMID 29650983›Full record

ArticleScientific reports2018

Myotube elasticity of an amyotrophic lateral sclerosis mouse model.

Béla Varga, Marta Martin-Fernandez, Cécile Hilaire, Ana Sanchez-Vicente, Julie Areias, Céline Salsac, Frédéric J G Cuisinier, Cédric Raoul, Frédérique Scamps, Csilla Gergely

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Béla VargaL2C, Univ Montpellier, CNRS, Montpellier, France.
Marta Martin-FernandezL2C, Univ Montpellier, CNRS, Montpellier, France.
Cécile HilaireINM, INSERM, Univ Montpellier, Montpellier, France.
Ana Sanchez-VicenteINM, INSERM, Univ Montpellier, Montpellier, France.
Julie AreiasINM, INSERM, Univ Montpellier, Montpellier, France.
Céline SalsacINM, INSERM, Univ Montpellier, Montpellier, France.
Frédéric J G CuisinierLBN, Univ Montpellier, Montpellier, France.
Cédric RaoulINM, INSERM, Univ Montpellier, Montpellier, France.
Frédérique ScampsINM, INSERM, Univ Montpellier, Montpellier, France.
Csilla GergelyL2C, Univ Montpellier, CNRS, Montpellier, France. csilla.gergely@umontpellier.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor system leading to generalized paralysis and death of patients. The understanding of early pathogenic mechanisms will help to define early diagnostics criteria that will eventually provide basis for efficient therapeutics. Early symptoms of ALS usually include muscle weakness or stiffness. Therefore, mechanical response of differentiated myotubes from primary cultures of mice, expressing the ALS-causing SOD1

Indexed as

ActinsAmyotrophic Lateral SclerosisAnimalsCell DifferentiationDisease Models, AnimalElasticityGene Expression RegulationHumansMechanical PhenomenaMiceMicroscopy, Atomic ForceMuscle DevelopmentMuscle Fibers, SkeletalMuscle WeaknessMutationMyosinsActinsMyosinsSod1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID29650983
PMCPMC5897453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.