Evidence map›Paper›PMID 29651006›Full record

ArticleScientific reports2018

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.

Evgenia Lampropoulou, Ioanna Logoviti, Marina Koutsioumpa, Maria Hatziapostolou, Christos Polytarchou, Spyros S Skandalis, Ulf Hellman, Manolis Fousteris, Sotirios Nikolaropoulos, Efrosini Choleva and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Evgenia LampropoulouLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Ioanna LogovitiLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Marina KoutsioumpaLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Maria HatziapostolouDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, United Kingdom.ORCID 0000-0003-2493-7028
Christos PolytarchouDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, United Kingdom.
Spyros S SkandalisLaboratory of Biochemistry, Department of Chemistry, University of Patras, GR26504, Patras, Greece.
Ulf HellmanLudwig Institute for Cancer Research, Uppsala University, Uppsala, SE-751-05, Sweden.
Manolis FousterisLaboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Sotirios NikolaropoulosLaboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Efrosini CholevaLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Margarita LamprouLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece.
Angeliki SkouraComputer Engineering and Informatics Department, University of Patras, Patras, Greece.
Vasileios MegalooikonomouComputer Engineering and Informatics Department, University of Patras, Patras, Greece.
Evangelia PapadimitriouLaboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504, Patras, Greece. epapad@upatras.gr.
University of Patras · GRNottingham Trent University · GBUppsala University · SEUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and α

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsCarbazolesCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell MovementCyclin-Dependent Kinase 5CytokinesGene Expression RegulationGuanineHumansHuman Umbilical Vein Endothelial CellsIntegrin alphaVbeta3IsoenzymesAdaptor Proteins, Signal TransducingCarbazolesCarrier ProteinsCDCA5 protein, humanCDK5 protein, humanCell Cycle ProteinsCyclin-Dependent Kinase 5CytokinesGuanineIntegrin alphaVbeta3IsoenzymesNU2058Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorspleiotrophinProtein Kinase InhibitorsReceptor-Like Protein Tyrosine Phosphatases, Class 5Roscovitine

Identifiers

PMID29651006
PMCPMC5897396
OpenAlexW2805062234

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.