Evidence map›Paper›PMID 29656143›Full record

ArticleOsteoarthritis and cartilage2018

Quantitative imaging of bone-cartilage interactions in ACL-injured patients with PET-MRI.

F Kogan, A P Fan, U Monu, A Iagaru, B A Hargreaves, G E Gold

Open access · bronzeAbstract read
In one paragraph

Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Validation of quantitative [Annals of nuclear medicine · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  5. Article
  6. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Effects of dynamic [Frontiers in nuclear medicine · 2023
    Article
  15. AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.International journal of molecular sciences · 2022
    Article
  16. Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022
    Review
  17. Review
  18. [Osteoarthritis and cartilage · 2021
    Article
  19. Assessment of quantitative [Osteoarthritis and cartilage · 2021
    Article
  20. [Frontiers in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

F KoganDepartment of Radiology, Stanford University, Stanford, CA, USA. Electronic address: fkogan@stanford.edu.
A P FanDepartment of Radiology, Stanford University, Stanford, CA, USA.
U MonuDepartment of Radiology, Stanford University, Stanford, CA, USA.
A IagaruDepartment of Radiology, Stanford University, Stanford, CA, USA.
B A HargreavesDepartment of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
G E GoldDepartment of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Stanford University · US

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Quantitative 3D Diffusion and Relaxometry MRI of the KneeR01AR063643 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2013 to 2017
$2.5M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
Quantitative Assessment of Early Metabolic and Biochemical Changes in OsteoarthritisK99EB022634 · NIBIB · STANFORD UNIVERSITY · PI KOGAN, FELIKS · 2017 to 2018
$184k
NIAMS NIH HHS K24 AR062068NIAMS NIH HHS R01 AR063643NIBIB NIH HHS K99 EB022634NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

objectiveTo investigate changes in bone metabolism by positron emission tomography (PET), as well as spatial relationships between bone metabolism and magnetic resonance imaging (MRI) quantitative markers of early cartilage degradation, in anterior cruciate ligament (ACL)-reconstructed knees.

designBoth knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of

resultsSignificantly increased subchondral bone

conclusions

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyAdultAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionBone RemodelingCartilage, ArticularCross-Sectional StudiesFemaleHumansKnee JointMaleBone–cartilage interactionsBone remodelingOsteoarthritisPET–MRI

Identifiers

PMID29656143
PMCPMC6037170
OpenAlexW2797887052

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.